Non Hdl Cholesterol Normal Range

Understanding the Normal Range for Non-HDL Cholesterol

Introduction to Non-HDL Cholesterol

Non-HDL cholesterol (non-HDL-C) is a critical marker for assessing cardiovascular risk. It includes all cholesterol contained in lipoprotein particles that are considered atherogenic, such as low-density lipoprotein (LDL) and very-low-density lipoprotein (VLDL). Unlike LDL-C, non-HDL-C provides a more comprehensive measure of all potentially harmful cholesterol particles.

Normal Range for Non-HDL Cholesterol

General Population

In a large-scale study involving 1.3 million U.S. adults, non-HDL-C values corresponding to LDL-C cutpoints were identified. For instance, LDL-C cutpoints of 70, 100, 130, 160, and 190 mg/dL matched non-HDL-C values of 93, 125, 157, 190, and 223 mg/dL, respectively. This study suggests that non-HDL-C cutpoints are generally 30 mg/dL higher than LDL-C cutpoints.

Children and Adolescents

A study focusing on Japanese children and adolescents found that the mean non-HDL-C level was 105.7 mg/dL, with boys averaging 103.0 mg/dL and girls 108.2 mg/dL. The 75th percentile for boys ranged from 113 to 120 mg/dL, while for girls, it was around 122 mg/dL. The 95th percentile was approximately 140 mg/dL for boys and 150 mg/dL for girls.

Adults with Normal or Near-Normal Triglycerides

In a Venezuelan population study, the median non-HDL-C was 143 mg/dL, with no significant difference between men and women. Non-HDL-C levels between 130-159 mg/dL and ≥160 mg/dL were associated with a higher risk of multiple atherosclerotic cardiovascular disease (ASCVD) risk factors.

Clinical Implications

Risk Stratification

Non-HDL-C is considered a superior predictor of cardiovascular risk compared to LDL-C, especially in individuals with high triglyceride levels. Studies have shown that non-HDL-C better reflects the presence of small-dense LDL particles, which are more atherogenic. This makes non-HDL-C a valuable tool for risk stratification and management in clinical practice.

Treatment Guidelines

Current guidelines suggest that non-HDL-C cutpoints for high-risk patients may need to be lowered to match the percentiles of LDL-C cutpoints. This adjustment could lead to a significant reclassification of patients into higher treatment categories, thereby improving risk assessment and treatment outcomes.

Conclusion

Non-HDL cholesterol is a crucial marker for assessing cardiovascular risk, with normal ranges varying by age, sex, and population. It provides a more comprehensive measure of atherogenic cholesterol compared to LDL-C, making it a valuable tool in both primary and secondary prevention of cardiovascular diseases. Understanding and utilizing the appropriate non-HDL-C cutpoints can significantly enhance patient care and outcomes.

Summary

Not a yes or no question

Understanding the Normal Range for Non-HDL Cholesterol

Introduction to Non-HDL Cholesterol

Normal Range for Non-HDL Cholesterol

General Population

Children and Adolescents

Adults with Normal or Near-Normal Triglycerides

Clinical Implications

Risk Stratification

Treatment Guidelines

Conclusion

Sources and full results

Reference Ranges for the Non-High-Density Lipoprotein Cholesterol Levels in Japanese Children and Adolescents.

Non-high-density lipoprotein cholesterol, guideline targets, and population percentiles for secondary prevention in 1.3 million adults: the VLDL-2 study (very large database of lipids).

Non-HDL cholesterol is better than LDL-c at predicting atherosclerotic cardiovascular disease risk factors clustering, even in subjects with near-to-normal triglycerides: A report from a Venezuelan population

National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries

Non-HDL Cholesterol is a More Superior Predictor of Small-Dense LDL Cholesterol than LDL Cholesterol in Japanese Subjects with TG Levels <400 mg/dL

Discordance between high non-HDL cholesterol and high LDL-cholesterol among US adults.

Repositioning of the global epicentre of non-optimal cholesterol

Non-HDL cholesterol is less informative than the total-to-HDL cholesterol ratio in predicting cardiovascular risk in type 2 diabetes.

Distribution and correlates of non-high-density lipoprotein cholesterol in children: the Bogalusa Heart Study.

Non-HDL cholesterol is a better target for predicting periprocedural myocardial injury following percutaneous coronary intervention in type 2 diabetes.

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