Nr supplement
Pro Research Analysisby 
Searched over 200M research papers for "nr supplement"
Consensus Meter
Nicotinamide Riboside (NR) Supplement: Insights from Recent Research
Introduction to Nicotinamide Riboside (NR)
Nicotinamide riboside (NR) is a precursor to nicotinamide adenine dinucleotide (NAD+), a vital coenzyme involved in numerous metabolic processes. As a member of the vitamin B-3 family, NR has garnered attention for its potential health benefits, particularly in the context of aging, metabolic health, and cellular function.
NR Supplementation and Metabolic Health
Insulin Sensitivity and Glucose Metabolism
Several studies have investigated the effects of NR on insulin sensitivity and glucose metabolism. A 12-week clinical trial involving obese, insulin-resistant men found that NR supplementation did not improve insulin sensitivity, glucose disposal, or oxidation. Similarly, another study with overweight and obese participants reported no significant effects on insulin sensitivity or mitochondrial function after 6 weeks of NR supplementation. These findings suggest that while NR is safe, it may not significantly impact insulin sensitivity or glucose metabolism in these populations.
Body Composition and Energy Metabolism
NR supplementation has shown some effects on body composition and energy metabolism. In a study with healthy obese individuals, NR increased body fat-free mass and sleeping metabolic rate, although it did not affect overall energy metabolism or mitochondrial function. Another study found that NR supplementation improved muscle quality and function in middle-aged mice, indicating potential benefits for physical performance and muscle health.
NR and Aging
Skeletal Muscle and Mitochondrial Function
Research has demonstrated that NR can elevate NAD+ levels in aged human skeletal muscle, leading to changes in the muscle NAD+ metabolome and anti-inflammatory effects. However, NR did not significantly alter mitochondrial bioenergetics or improve muscle regeneration after injury in elderly individuals. These findings highlight NR's potential to modulate muscle metabolism and inflammation, though its impact on muscle recovery and regeneration remains unclear.
Inflammation and Redox Homeostasis
NR has been shown to reduce certain inflammatory markers and improve redox homeostasis, particularly in older individuals. Studies have reported reductions in circulating inflammatory cytokines and oxidative stress markers following NR supplementation . These anti-inflammatory effects may contribute to NR's potential as a supplement for healthy aging, especially in populations with higher baseline inflammation.
NR in Clinical Applications
Cardiovascular and Neurodegenerative Disorders
Accumulating evidence supports NR's potential benefits for cardiovascular and neurodegenerative disorders. By increasing NAD+ levels, NR may help mitigate metabolic dysfunctions associated with these conditions. However, more research is needed to fully understand its therapeutic potential and establish effective dosing regimens.
Safety and Bioavailability
NR supplementation has been consistently shown to be safe across various studies, with no serious adverse events reported . However, challenges related to its bioavailability and the optimal dosing for different health outcomes remain areas for further investigation.
Conclusion
Nicotinamide riboside (NR) supplementation holds promise for enhancing metabolic health, supporting muscle function, and reducing inflammation, particularly in aging populations. While its effects on insulin sensitivity and glucose metabolism appear limited, NR's potential benefits for muscle health, redox homeostasis, and inflammation warrant further exploration. As research continues, NR may become a valuable supplement for promoting healthy aging and managing age-related conditions.
Sources and full results
Most relevant research papers on this topic