Olive leaf extract dosage and safety
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Olive Leaf Extract Dosage for Blood Pressure, Inflammation, and Metabolic Health
Dosage for Blood Pressure Reduction
Clinical studies in humans have shown that olive leaf extract is effective in lowering blood pressure at doses of 500 mg twice daily (total 1,000 mg/day) over 8 weeks, with results comparable to the antihypertensive drug captopril for stage-1 hypertension 146. Meta-analyses confirm that 1,000 mg/day can reduce systolic blood pressure by about 11 mmHg and diastolic by about 4–5 mmHg, while 500 mg/day also shows a significant reduction in systolic blood pressure, though the effect on diastolic pressure is less pronounced 46. Animal studies support a dose-dependent effect, with higher doses (25–50 mg/kg in rats) producing greater blood pressure reductions .
Dosage for Anti-Inflammatory and Analgesic Effects
In animal models, olive leaf extract at doses of 200–400 mg/kg demonstrated significant anti-inflammatory activity, reducing markers like TNF, IL-1, COX-2, and NO, and inhibiting inflammation-induced swelling . Analgesic effects were observed at 50–200 mg/kg, with higher doses providing greater pain relief and also enhancing the effects of morphine .
Dosage for Metabolic and Glycemic Control
For glycemic control in adults with type 2 diabetes, a daily dose of 500 mg has been shown to improve glucose homeostasis and lower HbA1c and fasting insulin levels over 14 weeks . However, a 24-week pilot study found no significant difference in HbA1c compared to placebo, though the extract was well-tolerated . In animal studies, doses of 50–100 mg/kg/day improved lipid profiles and provided neuroprotection .
Dosage for Reproductive and Organ Health
In rat studies, oral administration of 250–500 mg/kg/day of olive leaf extract helped repair testicular damage and improve sperm quality after toxic exposure, but a higher dose of 750 mg/kg/day was not beneficial and could worsen some effects .
Safety and Tolerability of Olive Leaf Extract
Human Studies
Clinical trials in adults with hypertension, prehypertension, and type 2 diabetes report that olive leaf extract at doses up to 1,000 mg/day is generally well-tolerated, with no severe or serious adverse events reported 146710. Safety parameters for kidney and liver function remained stable during these studies .
Animal Studies
Acute oral administration of olive leaf extract up to 4 g/kg in rats was considered safe, with no observed toxicity . However, very high doses (e.g., 750 mg/kg/day in rats) may have adverse effects on reproductive organs and liver enzymes .
Conclusion
Olive leaf extract is generally safe and well-tolerated in humans at doses up to 1,000 mg/day, with evidence supporting its use for lowering blood pressure, reducing inflammation, and improving metabolic health. In animal studies, lower to moderate doses are effective and safe, while very high doses may cause harm. For most adults, a daily dose of 500–1,000 mg appears effective and safe for cardiovascular and metabolic benefits. As with any supplement, individuals should consult healthcare providers before starting olive leaf extract, especially at higher doses or for long-term use.
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