Olive leaf extract safety
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Olive Leaf Extract Safety in Human and Animal Studies
Human Clinical Trials and Tolerability
Research in adults with type 2 diabetes shows that olive leaf extract (OLE) is well-tolerated over a 24-week period, with no severe or serious adverse events reported. This suggests that OLE is generally safe for human consumption in the studied doses and duration, although larger studies are needed to confirm these findings and further assess long-term safety and efficacy .
Animal Studies and High-Dose Safety
Animal studies have tested OLE at high doses (up to 4 g/kg) in rats and found it to be generally safe, with no significant toxicity observed. These studies support the idea that OLE has a wide safety margin in animal models 24.
Toxicity and Safety Reviews
Reviews of the literature indicate that olive leaf and its extracts are considered safe, even at high doses, based on available toxicity studies. However, most of the current evidence comes from cell culture and animal studies, and more extensive human clinical trials are needed to fully confirm safety in people .
Protective Effects and Lack of Adverse Outcomes
OLE has shown protective effects in animal models, such as preventing liver injury and gastritis, without causing harm to the animals. These studies further support the safety profile of OLE, as no adverse outcomes were reported during the experiments 567.
Conclusion
Current evidence from human and animal studies suggests that olive leaf extract is generally safe and well-tolerated, even at relatively high doses. No severe or serious adverse effects have been reported in clinical or preclinical studies. However, most safety data come from animal research and small-scale human trials, so larger and longer-term studies in humans are needed to confirm these findings and ensure comprehensive safety evaluation 124567.
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