Omeprazole interactions with alcohol

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Omeprazole and Alcohol Metabolism: Drug Interaction Insights

Omeprazole’s Effect on Ethanol Metabolism and Blood Alcohol Levels

Multiple studies have shown that omeprazole does not significantly affect the metabolism of ethanol in humans. Unlike some H2-receptor antagonists such as cimetidine, which can increase blood alcohol concentrations by inhibiting gastric alcohol dehydrogenase (ADH), omeprazole does not alter the first-pass metabolism of ethanol or the activity of gastric ADH in humans or rats. This means that omeprazole does not lead to higher blood alcohol levels after drinking alcohol, making it a safer option for patients who may consume alcohol during therapy for gastric conditions 1235.

Omeprazole and Gastric Mucosal Protection Against Alcohol-Induced Damage

Research on the protective effects of omeprazole against alcohol-induced gastric mucosal injury has produced mixed results. Some animal studies suggest that omeprazole can protect the stomach lining from ethanol-induced lesions, possibly through mechanisms unrelated to prostaglandin synthesis or acid inhibition . However, other studies indicate that omeprazole may not protect, and could even worsen, ethanol-induced gastric mucosal damage, especially at high doses that significantly increase gastrin levels and cause changes in gastric cell populations . Newer research also explores combinations of omeprazole with other agents, such as patchouli alcohol or functional drinks, which may enhance gastric protection and reduce inflammation and oxidative stress in alcohol-induced gastric ulcer models 710.

Omeprazole Solubility and Ethanol as a Cosolvent

Experimental data show that the solubility of omeprazole increases in the presence of ethanol, especially at higher temperatures. However, these findings are primarily relevant to pharmaceutical formulation and do not indicate any clinically significant interaction between omeprazole and alcohol in terms of drug efficacy or safety for patients .

Conclusion

Current evidence indicates that omeprazole does not interact with alcohol in a way that affects ethanol metabolism or increases blood alcohol levels in humans. While omeprazole may offer some protection against alcohol-induced gastric injury, results are mixed and may depend on dosage and individual patient factors. Overall, omeprazole is considered a safe choice for patients who may consume alcohol during therapy, especially compared to certain H2-receptor antagonists 1235.

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Most relevant research papers on this topic

Effects of omeprazole on ethanol metabolism: an in vitro and in vivo rat and human study.

Omeprazole does not affect ethanol metabolism in humans and is safer than cimetidine for patients unable to reduce ethanol intake during therapy for peptic ulcer or other hypersecretory conditions.

Non-RCT

1994·

13citations

·Gabriele Pozzato et al.

Effect of omeprazole on gastric first-pass metabolism of ethanol

Omeprazole does not affect gastric first-pass metabolism of ethanol, making it a safe choice for patients who do not abstain from alcohol consumption during therapy.

Non-RCT

1992·

7citations

·R. Roine et al.

Omeprazole therapy does not affect pharmacokinetics of orally administered ethanol in healthy male subjects.

Omeprazole therapy (20 mg twice daily) does not affect the pharmacokinetics of orally ingested ethanol in healthy male subjects, but may potentially affect psychomotor function due to pharmacodynamic interactions.

Non-RCT

1995·

8citations

·A. Minocha et al.

Effects of omeprazole on ethanol lesions.

Omeprazole has no protective effect on ethanol-induced gastric mucosa damage and may worsen lesions, making it a potential drug for patients refractory to standard H2-receptor antagonist therapy.

Non-RCTAnimal Study

2000·

9citations

·N. A. Abdel Fattaha et al.

Hepatic glutathione after ethanol administration in rat: effects of cimetidine and omeprazole.

Inhibiting gastric alcohol dehydrogenase (ADH) with ethanol intake leads to a more severe depletion of hepatic glutathione, potentially causing liver damage.

Non-RCTAnimal Study

1995·

2citations

·L. Battiston et al.

Protective action of omeprazole, a benzimidazole derivative, on gastric mucosal damage by aspirin and ethanol in rats.

Omeprazole protects gastric mucosa from acidified aspirin and ethanol-induced injury, with its protective effect unrelated to gastric inhibition or mucosal prostaglandin biosynthesis.

Non-RCTAnimal StudyHighly Cited

1983·

70citations

·Konturek Sj et al.

A potential drug combination of omeprazole and patchouli alcohol significantly normalizes oxidative stress and inflammatory responses against gastric ulcer in ethanol-induced rat model.

The combination of omeprazole and patchouli alcohol effectively reduces gastric ulcer areas, modulates oxidative stress, and reduces inflammatory factors in ethanol-induced rat models, potentially playing a crucial role in gastric mucosa protection.

Non-RCTAnimal StudyRigorous Journal

2020·

42citations

·Lu Xie et al.

Experimental solubility of omeprazole in pure and ethanol-modified subcritical water

Omeprazole's solubility in subcritical water increases with temperature and ethanol concentration, with the highest solubility achieved at 130°C with 10% ethanol as a cosolvent.

2024·

0citations

·Meysam Salehian et al.

Argel's stemmoside C as a novel natural remedy for mice with alcohol-induced gastric ulcer based on its molecular mechanistic pathways.

Stemmoside C, a phytochemical from Solenostemma argel, effectively protects the stomach against ethanol-induced gastric ulcers in mice, offering a potential alternative to Omeprazole with limited side effects.

Non-RCTAnimal Study

2024·

5citations

·Ghazal Nabil et al.

Multi-trace elements-enriched functional drink accelerates gastric ulcer repair via the HGF/c-Met/STAT3 pathway

A functional drink enriched with trace elements accelerates gastric ulcer repair by promoting antioxidant factors, decreasing inflammation, and regulating intestinal flora.

RCT

2025·

0citations

·Yongnan Piao et al.

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