Omeprazole interactions with dietary supplements
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Omeprazole Interactions with Dietary Supplements: Key Insights
Grape Juice and Omeprazole Pharmacokinetics
Consuming grape juice as a dietary supplement can significantly reduce the effectiveness of omeprazole. When omeprazole is taken with grape juice, its absorption in the body decreases, as shown by a 32% reduction in overall exposure (AUC) and a 34% reduction in peak concentration (Cmax). This interaction is likely due to grape juice activating certain enzymes (CYP3A4, CYP2C19) and transporters (P-glycoprotein) that metabolize omeprazole more quickly. As a result, patients who regularly consume grape juice may need higher doses of omeprazole to achieve the same therapeutic effect .
Gallic Acid Supplementation and Omeprazole Side Effects
Gallic acid, a compound found in many fruits and dietary supplements, may help counteract some negative effects of omeprazole. In animal studies, gallic acid supplementation reduced omeprazole-induced depression-like behavior and memory problems. It also improved antioxidant activity and normalized neurotransmitter levels in the brain. This suggests that gallic acid could be a beneficial dietary supplement for people experiencing neurological side effects from omeprazole use .
Melatonin, Vitamins, Amino Acids, and GERD Symptom Relief
A dietary supplement containing melatonin, l-tryptophan, vitamin B6, folic acid, vitamin B12, methionine, and betaine was found to be more effective than omeprazole alone in relieving symptoms of gastroesophageal reflux disease (GERD). In a clinical study, all patients taking the supplement reported complete symptom relief after 40 days, compared to about two-thirds of those taking omeprazole. This combination supplement may offer an alternative or complementary approach to managing GERD symptoms, with no significant side effects reported .
Omeprazole and Vitamin B12 (Cyanocobalamin) Absorption
Long-term use of omeprazole can lead to vitamin B12 deficiency. Omeprazole reduces stomach acid, which is necessary for releasing vitamin B12 from food so it can be absorbed. Studies show that after just two weeks of omeprazole therapy, the absorption of protein-bound vitamin B12 drops significantly. Over time, this can result in low vitamin B12 levels, which may cause serious neurological and blood-related problems if not addressed. People taking omeprazole for extended periods should monitor their vitamin B12 status and consider supplementation if needed .
Omeprazole, Dietary Nitrate, and Vitamin C Levels
Omeprazole, especially when combined with a diet high in nitrates (such as from leafy greens or certain vegetables), can lower vitamin C (ascorbic acid) levels in the stomach. This change increases the risk of forming potentially harmful nitrite compounds, which may raise the risk of gastric cancer. The effect is even more pronounced in people with Helicobacter pylori infection. Therefore, individuals on omeprazole therapy should be aware of their vitamin C intake and consider supplementation if necessary .
Conclusion
Omeprazole interacts with several dietary supplements and nutrients, affecting both its own effectiveness and the body’s nutritional status. Grape juice can reduce omeprazole absorption, while gallic acid may help with omeprazole-induced neurological side effects. A combination supplement of melatonin, vitamins, and amino acids may be more effective than omeprazole alone for GERD symptoms. Long-term omeprazole use can cause vitamin B12 deficiency, and it can also lower vitamin C levels when combined with dietary nitrates. Patients using omeprazole should be mindful of these interactions and may benefit from monitoring and adjusting their supplement intake accordingly.
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