Pantoprazole nursing considerations

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Nursing Considerations for Pantoprazole Administration

Predictive Nursing and Pantoprazole for Gastric Bleeding

Efficacy of Predictive Nursing Interventions

Predictive nursing interventions combined with pantoprazole and digestive endoscopy have shown significant efficacy in treating gastric hemorrhage. In a study comparing routine nursing interventions with predictive nursing interventions, patients receiving predictive nursing had a higher total effective rate and shorter hospital stays. Specifically, the length of stay for the predictive nursing group was significantly reduced to approximately 4.82 days compared to 8.19 days in the control group . This approach also led to higher nursing satisfaction and a reduction in complications and recurrent bleeding .

Clinical Outcomes and Nursing Satisfaction

The study highlighted that predictive nursing combined with pantoprazole not only improves clinical outcomes but also enhances patient satisfaction with nursing care. This suggests that integrating predictive nursing strategies can be beneficial in clinical settings, particularly for patients undergoing treatment for gastric hemorrhage .

Pantoprazole Use in ICU Patients

Prophylaxis for Gastrointestinal Bleeding

Pantoprazole is frequently used as a prophylactic treatment for gastrointestinal stress ulceration in ICU patients. A large multicenter trial evaluated the risks and benefits of administering 40 mg of intravenous pantoprazole daily to ICU patients at risk for gastrointestinal bleeding. The study found no significant difference in 90-day mortality rates between the pantoprazole group and the placebo group, with mortality rates of 31.1% and 30.4%, respectively .

Clinically Important Events and Safety

The incidence of clinically important events, including gastrointestinal bleeding, pneumonia, Clostridium difficile infection, and myocardial ischemia, was similar between the pantoprazole and placebo groups. However, the pantoprazole group had a lower incidence of clinically important gastrointestinal bleeding (2.5%) compared to the placebo group (4.2%) . The study also reported no significant differences in the number of infections, serious adverse reactions, or the percentage of days alive without life support within 90 days between the two groups .

Conclusion

Pantoprazole, when combined with predictive nursing interventions, is effective in treating gastric hemorrhage, reducing hospital stays, and improving nursing satisfaction. In ICU settings, pantoprazole is a viable option for gastrointestinal bleeding prophylaxis, although it does not significantly impact overall mortality or the incidence of clinically important events compared to placebo. These findings underscore the importance of tailored nursing interventions and careful consideration of pantoprazole's benefits and risks in different clinical scenarios.

Sources and full results

Most relevant research papers on this topic

Efficacy Evaluation of Predictive Nursing Combined with Pantoprazole and Digestive Endoscopy for Treatment of Gastric Bleeding

Predictive nursing combined with pantoprazole and digestive endoscopy effectively treats gastric bleeding, shortens hospital stays, reduces complications, and improves nursing satisfaction.

RCT

2020·

0citations

·Xiang-yang Huang

Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU

Pantoprazole and placebo show similar mortality rates and clinically important events in adult ICU patients at risk for gastrointestinal bleeding.

RCTLarge Human TrialRigorous JournalHighly Cited

2018·

227citations

·M. Krag et al.

Pantoprazole or Placebo for Stress Ulcer Prophylaxis (POP-UP): Randomized Double-Blind Exploratory Study*

Pantoprazole prophylaxis in mechanically ventilated critically ill patients does not show evidence of benefit or harm, warranting further evaluation.

RCTHighly Cited

2016·

81citations

·Shane P. Selvanderan et al.

Heterogeneity of treatment effect of prophylactic pantoprazole in adult ICU patients: a post hoc analysis of the SUP-ICU trial

Prophylactic pantoprazole may increase the risk of serious adverse events in patients with greater illness severity or more risk factors for gastrointestinal bleeding.

Rigorous Journal

2020·

27citations

·A. Granholm et al.

Pantoprazole

Pantoprazole is an effective agent for managing acid-related disorders, with similar efficacy to other PPIs and greater efficacy than histamine H(2)-antagonists.

Non-RCTHighly Cited

2012·

132citations

·S. Cheer et al.

Withholding Pantoprazole for Stress Ulcer Prophylaxis in Critically Ill Patients: A Pilot Randomized Clinical Trial and Meta-Analysis*

Withholding pantoprazole for stress ulcer prophylaxis in critically ill patients did not increase the risk of upper gastrointestinal bleeding, and the effect of proton pump inhibitors on ventilator-associated pneumonia and Clostridium difficile remains unclear.

Meta-AnalysisRigorous JournalHighly Cited

2017·

83citations

·W. Alhazzani et al.

Efficacy and Safety of Pantoprazole Delayed-release Granules for Oral Suspension in a Placebo-controlled Treatment-withdrawal Study in Infants 1–11 Months Old With Symptomatic GERD

Pantoprazole significantly improved GERD symptom scores in infants and was well-tolerated, but during the randomized, double-blind, placebo-controlled treatment phase, no significant differences were found in withdrawal rates due to lack of efficacy.

RCTVery Rigorous JournalHighly Cited

2010·

71citations

·H. Winter et al.

Pantoprazole, an Inhibitor of the Organic Cation Transporter 2, Does Not Ameliorate Cisplatin‐Related Ototoxicity or Nephrotoxicity in Children and Adolescents with Newly Diagnosed Osteosarcoma Treated with Methotrexate, Doxorubicin, and Cisplatin

Pantoprazole, an inhibitor of organic cation transporter 2, did not improve cisplatin-related ototoxicity or nephrotoxicity in children and adolescents with osteosarcoma treated with methotrexate, doxorubicin, and cisplatin.

RCT

2018·

33citations

·E. Fox et al.

Single-dose, multiple-dose, and population pharmacokinetics of pantoprazole in neonates and preterm infants with a clinical diagnosis of gastroesophageal reflux disease (GERD)

Pantoprazole granules were generally well-tolerated and well-tolerated in preterm infants and neonates with gastroesophageal reflux disease, with mean exposures slightly higher than in adults and no accumulation observed.

RCTVery Rigorous Journal

2010·

56citations

·R. Ward et al.

Pantoprazole to Prevents Gastroduodenal Events in Patients Receiving Rivaroxaban and/or Aspirin in a Randomized, Double-blind, Placebo-controlled Trial.

Pantoprazole reduces bleeding from gastroduodenal lesions in patients receiving low-dose anticoagulation and/or aspirin for stable cardiovascular disease, but does not significantly reduce upper gastrointestinal events.

RCTLarge Human TrialHighly Cited

2019·

98citations

·P. Moayyedi et al.

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