Phosphorus supplement
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Phosphorus Supplementation: Insights from Recent Research
Phosphorus Supplementation in Preterm Infants
Effects on Growth and Bone Health
Phosphorus supplementation in preterm or low birth weight infants has been studied to determine its impact on growth and bone health. Research indicates that while phosphorus supplementation can reduce the incidence of osteopenia in these infants, it does not significantly affect other growth parameters such as weight, length, and head circumference 12. Additionally, the supplementation does not appear to influence serum calcium and phosphorus levels or alkaline phosphatase activity significantly 12. The evidence from these studies is considered to be of low quality, and there is insufficient data to conclude whether phosphorus supplementation is beneficial or harmful for preterm infants 12.
Phosphorus Supplementation in Adults
Impact on Weight and Metabolic Health
In adults, phosphorus supplementation has shown promising results in managing obesity. A randomized clinical trial demonstrated that phosphorus supplementation over 12 weeks significantly reduced body weight, BMI, waist circumference, and subjective appetite scores in overweight and obese adults . These findings suggest that phosphorus could play a role in weight management and the prevention of obesity-related conditions.
Effects on Nutrient Absorption and Metabolism
Phosphorus supplementation also affects nutrient absorption and metabolism. Studies have shown that dietary phosphorus can regulate serum fibroblast growth factor-23 (FGF-23) concentrations, which in turn influences vitamin D metabolism and phosphate homeostasis . Additionally, phosphorus supplementation has been found to modulate blood lipids positively and enhance the absorption of calcium and phosphorus in the intestines .
Phosphorus Supplementation in Animal Models
Growth and Nutrient Utilization
Animal studies provide further insights into the effects of phosphorus supplementation. In rats fed a low-protein diet, phosphorus supplementation improved food intake, weight gain, and energy efficiency, suggesting that phosphorus can mitigate the adverse effects of low protein intake on growth . Similarly, in broiler chickens, phosphorus supplementation, especially when combined with phytase, enhanced the utilization of natural phytate phosphorus, leading to better growth and bone health 910.
Stress Tolerance and Nutrient Interaction
Phosphorus supplementation has also been shown to improve stress tolerance in plants. For instance, in mustard plants, phosphorus supplementation mitigated arsenic stress by enhancing nitric oxide biosynthesis and stabilizing the antioxidant defense system, thereby protecting photosynthesis and promoting growth . This highlights the potential of phosphorus in enhancing stress tolerance and nutrient interaction in various biological systems.
Conclusion
Phosphorus supplementation has diverse effects across different populations and biological systems. In preterm infants, the benefits are still uncertain due to low-quality evidence. However, in adults, phosphorus shows potential in weight management and metabolic health. Animal studies further support the role of phosphorus in improving growth and nutrient utilization. Future research should focus on elucidating the mechanisms of action and long-term effects of phosphorus supplementation to better understand its potential benefits and risks.
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