Prilosec mechanism of action

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Prilosec Mechanism of Action

Introduction to Prilosec (Omeprazole)

Prilosec, also known by its generic name omeprazole, is a widely used medication for the treatment of acid-related disorders. It belongs to a class of drugs known as proton-pump inhibitors (PPIs), which are designed to reduce the production of stomach acid.

Proton-Pump Inhibition

Mechanism of Action

Prilosec works by targeting the proton pumps in the stomach lining. These proton pumps, specifically the H+/K+ ATPase enzyme system, are responsible for the final step in the production of gastric acid. By inhibiting these proton pumps, Prilosec effectively reduces the secretion of gastric acid into the stomach .

Clinical Efficacy

The development of Prilosec marked a significant advancement in the treatment of acid-related disorders. It proved to be clinically superior to previous antisecretory drugs, offering better control over gastric acid secretion and providing relief from conditions such as gastroesophageal reflux disease (GERD) and peptic ulcers .

Combination Therapy with Mosapride

Enhanced Treatment for Reflux Esophagitis

Recent studies have explored the combined use of Prilosec with other medications to enhance its therapeutic effects. One such study investigated the combination of Prilosec with Mosapride, a prokinetic agent, in the treatment of senile reflux esophagitis. The results indicated that the combination therapy significantly improved the levels of stomach secretory elements and gastric motility elements, leading to better clinical outcomes compared to Prilosec alone .

Safety and Efficacy

The combination of Prilosec and Mosapride was found to be safe, with no significant adverse reactions reported during the treatment period. This combination therapy not only reduced the content of stomach reflux but also adjusted the stomach's secretory and motility functions, making it a recommended treatment method for reflux esophagitis .

Conclusion

Prilosec (omeprazole) is a potent proton-pump inhibitor that effectively reduces gastric acid production by inhibiting the H+/K+ ATPase enzyme system in the stomach lining. Its clinical efficacy has been well-documented, and recent studies suggest that combining Prilosec with Mosapride can further enhance its therapeutic effects, particularly in the treatment of reflux esophagitis. This combination therapy is both effective and safe, offering a promising approach for managing acid-related disorders.

Sources and full results

Most relevant research papers on this topic

The curative of prilosec joint Mosapride on treating senile reflux esophagitis

Prilosec joint Mosapride effectively reduces stomach content of reflux in elderly patients, with a distinct curative effect and safe drug use.

RCT

2012·

0citations

·Yao Jin

A proton-pump inhibitor expedition: the case histories of omeprazole and esomeprazole

Omeprazole and esomeprazole revolutionized treatment for acid-related disorders by improving antisecretory effects and enhancing clinical effects.

Highly Cited

2003·

362citations

·L. Olbe et al.

Case Study: Omeprazole (Prilosec®)

Omeprazole reduces gastric acid secretion by inhibiting the proton pump in the parietal cell, acting as a prodrug and converted to the active inhibitor in acidic compartments of the parietal cell.

2007·

6citations

·J. Hemenway

Site selective syntheses of [(3)H]omeprazole using hydrogen isotope exchange chemistry.

This study demonstrates a controlled and selective labeling of omeprazole with tritium using hydrogen isotope exchange chemistry, potentially benefiting drug discovery and development efforts.

2015·

6citations

·Scott R Pollack et al.

Omeprazole and clopidogrel: Should clinicians be worried?

Omeprazole reduces clopidogrel's antiplatelet activity by 50%, but a randomized clinical trial found no effect on cardiovascular outcomes when both drugs are used together.

2010·

36citations

·Jeremiah P. Depta et al.

Asthma and gastroesophageal reflux: acid suppressive therapy improves asthma outcome.

Acid suppressive therapy with omeprazole improves asthma symptoms and/or peak expiratory flow rates by >20% and pulmonary function in 73% of asthmatics with gastroesophageal reflux after 3 months of therapy.

Non-RCTHighly Cited

1996·

416citations

·S. Harding et al.

An overview of proton pump inhibitors.

Proton pump inhibitors are effective treatments for acid-related disorders, including gastroesophageal reflux disease, peptic ulcer disease, and Helicobacter pylori infection, with five approved drugs available in the US.

2003·

49citations

·G. Der

Omeprazole and Semen Quality.

Omeprazole does not appear to change semen quality, possibly due to its ability to counteract the damaging effects of reactive oxygen species and not alter hormone levels.

Systematic Review

2016·

9citations

·S. Banihani

Omeprazole as a cause of oral candidiasis.

Omeprazole effectively reduces stomach acid, but prolonged use can induce oral candidiasis in patients with peptic ulcers.

Case Report

1995·

3citations

·P. Anderson

Role of sulfur chirality in the chemical processes of biology.

Chiral sulfur compounds, such as Nexium, play a crucial role in biological processes, with their physiological behavior influencing general and secondary metabolism.

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·R. Bentley

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