Probiotic bloating
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Probiotic Bloating: Insights from Recent Research
Introduction to Probiotics and Bloating
Probiotics are live microorganisms that, when administered in adequate amounts, confer health benefits to the host. They are often used to manage various gastrointestinal issues, including bloating, a common symptom in both functional bowel disorders (FBD) and irritable bowel syndrome (IBS).
Efficacy of Bifidobacterium infantis 35624
Study on Non-Patients with Abdominal Discomfort
A study evaluated the efficacy of Bifidobacterium infantis 35624 in non-patients experiencing abdominal discomfort and bloating. The results indicated no significant improvement in the mean severity of symptoms compared to the placebo group, although there was a higher frequency of bloating-free days in the probiotic group1. This suggests that while B. infantis 35624 may not significantly reduce symptom severity, it could potentially increase symptom-free periods.
Study on Women with IBS
In contrast, another study focusing on women with IBS found that B. infantis 35624 significantly improved symptoms of abdominal pain, bloating, and other IBS-related symptoms at a specific dosage (1 × 10^8 cfu)6. This highlights the strain's potential effectiveness in a patient population with more severe symptoms.
Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07
Functional Bowel Disorders
Two studies investigated the effects of Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 on patients with FBDs. Both studies reported significant improvements in bloating and distention scores in the probiotic groups compared to placebo at both 4 and 8 weeks2 3. These findings support the role of these specific probiotic strains in managing bloating in FBD patients.
Bacillus coagulans
IBS Symptom Relief
A study on Bacillus coagulans GBI-30, 6086 demonstrated significant improvements in abdominal pain and bloating in IBS patients over an 8-week period compared to placebo10. This suggests that B. coagulans may be a promising probiotic for alleviating IBS symptoms, including bloating.
Meta-Analyses and Systematic Reviews
Probiotics in IBS
A systematic review and network meta-analysis identified B. coagulans as the most effective probiotic for improving IBS symptoms, including bloating4. Another review confirmed the efficacy of B. infantis 35624 in improving IBS symptoms, while highlighting the need for more robust studies on other probiotics7 8.
Functional Constipation
A meta-analysis on probiotics for functional constipation found that multispecies probiotics significantly decreased bloating compared to single-species probiotics5. This underscores the potential benefits of using a combination of probiotic strains for managing bloating in constipation.
Conclusion
The research indicates that specific probiotic strains, such as Bifidobacterium infantis 35624, Lactobacillus acidophilus NCFM, Bifidobacterium lactis Bi-07, and Bacillus coagulans, can be effective in reducing bloating, particularly in patients with IBS and FBDs. However, the efficacy can vary based on the population and the specific probiotic strain used. Further large-scale, well-designed studies are needed to confirm these findings and optimize probiotic treatments for bloating.
Sources and full results
Most relevant research papers on this topic
Multi-Center, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study to Evaluate the Benefit of the Probiotic Bifidobacterium infantis 35624 in Non-Patients With Symptoms of Abdominal Discomfort and Bloating
Bifidobacterium infantis 35624 did not significantly improve abdominal discomfort and bloating symptoms in a non-patient population, possibly due to a high placebo effect and lower impact of functional bowel symptoms.
RCT
Rigorous JournalProbiotic Bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 Versus Placebo for the Symptoms of Bloating in Patients With Functional Bowel Disorders: A Double-blind Study
Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 improve bloating symptoms in patients with functional bowel disorders, supporting their role in managing these disorders.
RCT
Highly CitedT1406 Probiotic Bacteria Lactobacillus Acidophilus Ncfm and Bifidobacterium Lactis Bi-07 Improve Symptoms of Bloating in Patients with Functional Bowel Disorders (FBD)
Probiotic bacteria LNCFM and B-LBi07 significantly improve symptoms of bloating and distention in patients with functional bowel disorders.
RCTEfficacy of Probiotics for Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis
B.coagulans probiotics show the highest efficacy in improving IBS symptoms, with B.coagulans showing the highest efficacy in abdominal pain and straining scores after 8 weeks of treatment.
Meta-AnalysisMeta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults.
Probiotics, particularly multispecies probiotics, can significantly reduce gut transit time, increase stool frequency, and improve stool consistency in adults with functional constipation.
Meta-Analysis
Very Rigorous JournalHighly CitedEfficacy of an Encapsulated Probiotic Bifidobacterium infantis 35624 in Women with Irritable Bowel Syndrome
Bifidobacterium infantis 35624, at a dose of 1 108 cfu, effectively relieves many IBS symptoms and is easily administered in capsule form.
RCT
Large Human TrialHighly CitedEfficacy of Prebiotics, Probiotics, and Synbiotics in Irritable Bowel Syndrome and Chronic Idiopathic Constipation: Systematic Review and Meta-analysis
Probiotics are effective treatments for irritable bowel syndrome, but the role of prebiotics and synbiotics in IBS remains unclear, and their efficacy in chronic idiopathic constipation is uncertain.
Meta-AnalysisRigorous JournalHighly CitedThe Utility of Probiotics in the Treatment of Irritable Bowel Syndrome: A Systematic Review
Bifidobacterium infantis 35624 shows efficacy for improving IBS symptoms, but most randomized controlled trials on probiotics in IBS lack appropriate study design and adverse event reporting.
Systematic ReviewHighly CitedThe effect of a probiotic blend on gastrointestinal symptoms in constipated patients: a double blind, randomised, placebo controlled 2-week trial.
A probiotic blend containing lactobacilli and bifidobacteria showed a significant decrease in flatulence and reduced overall digestive discomfort in adults with functional constipation.
RCTBacillus coagulans significantly improved abdominal pain and bloating in patients with IBS.
Bacillus coagulans GBI-30, 6086 probiotic may be a safe and effective option for relieving abdominal pain and bloating in patients with irritable bowel syndrome.
RCTHighly Cited