Probiotic supplements daily dose

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Daily Dose of Probiotic Supplements: Insights from Recent Research

Probiotic Supplementation and Weight Loss

Lab4P Probiotic Consortium
A study involving 70 overweight adults demonstrated that a daily dose of 50 billion CFU of the Lab4P probiotic, which includes lactobacilli and bifidobacteria, significantly reduced body weight, waist circumference, and hip circumference over a 9-month period . This suggests that high-dose probiotic supplementation can be effective for weight management in overweight individuals.

Dose-Response Effects of Multi-Strain Probiotics

General Adult Population
Research comparing low (5 billion CFU) and high (25 billion CFU) doses of a multi-strain probiotic supplement found no significant differences in gastrointestinal health or general wellness between the two doses over a 28-day period . This indicates that both low and high doses are well-tolerated and safe, but may not differ significantly in their effects on a healthy population.

Healthy Adults
Another study with healthy adults also compared 5 billion CFU and 25 billion CFU doses of a multi-strain probiotic over six weeks. The results showed no significant impact on gastrointestinal symptoms or general wellness, reinforcing the idea that both doses are safe and well-tolerated .

Probiotics in Specific Health Conditions

Type 2 Diabetes Mellitus (T2DM)
In a study with T2DM patients, a daily dose of 2.5 billion CFU of a multi-strain probiotic significantly improved glycemic control, reduced inflammation, and improved cardiometabolic profiles over six months . This suggests that even a moderate dose of probiotics can have substantial health benefits in individuals with metabolic disorders.

Gestational Diabetes Mellitus (GDM)
Pregnant women with GDM who took a daily dose of 6 billion CFU of a multi-strain probiotic for six weeks showed significant improvements in glycemic control and lipid profiles compared to a placebo group . This highlights the potential of probiotics in managing gestational diabetes.

Probiotics and Iron Metabolism

Obese Postmenopausal Women
A study on obese postmenopausal women found that both low (2.5 billion CFU) and high (10 billion CFU) doses of a multi-strain probiotic over 12 weeks influenced iron metabolism, with varying effects on serum zinc and ferritin levels . This indicates that probiotic supplementation can affect mineral metabolism, which may be dose-dependent.

Probiotics in Animal Studies

Dairy Cows
In dairy cows, a high dose (10 grams) of the yeast probiotic Saccharomyces cerevisiae significantly increased milk production compared to a lower dose (5 grams) . This suggests that higher doses of probiotics may be more effective in enhancing productivity in livestock.

Chicks
A study on chicks showed that a compound probiotic supplement (1,000 mg/kg) improved growth performance, intestinal health, and immune function, indicating the benefits of high-dose probiotics in animal health .

Conclusion

The optimal daily dose of probiotic supplements can vary depending on the specific health condition and population. High doses (up to 50 billion CFU) have shown significant benefits in weight management and metabolic health, while both low and high doses are generally well-tolerated and safe. Further research is needed to determine the most effective doses for different health outcomes.

Sources and full results

Most relevant research papers on this topic

Daily supplementation with the Lab4P probiotic consortium induces significant weight loss in overweight adults

Daily supplementation with Lab4P probiotics leads to significant weight loss and reduced waist and hip circumference in overweight adults.

RCTRigorous Journal

2021·

19citations

·D. Michael et al.

Safety and Effect of a Low- and High-Dose Multi-Strain Probiotic Supplement on Microbiota in a General Adult Population: A Randomized, Double-Blind, Placebo-Controlled Study

A high-dose multi-strain probiotic supplement was well-tolerated and minimally influenced microbiota composition in a general adult population without adverse events.

RCT

2020·

20citations

·A. Tremblay et al.

Dose effect of Actisaf Sc 47 yeast probiotic (Saccharomyces cerevisiae) supplementation on production, reproduction, and negative energy balance in early lactation dairy cows

Yeast probiotic supplementation with 10g dose significantly increases milk production in early lactation dairy cows, while both doses improve energy use and resource efficiency.

RCT

2023·

2citations

·Dana Kumprechtová et al.

Effects of a 6-month multi-strain probiotics supplementation in endotoxemic, inflammatory and cardiometabolic status of T2DM patients: A randomized, double-blind, placebo-controlled trial.

Multi-strain probiotic supplementation for 6 months significantly decreased insulin resistance and improved cardiometabolic profile in type 2 diabetes patients.

RCTVery Rigorous JournalHighly Cited

2019·

131citations

·S. Sabico et al.

Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: A randomized, double-blind, placebo-controlled trial.

Probiotic supplementation for 6 weeks in gestational diabetes patients improved glycemic control, triglycerides, and VLDL cholesterol concentrations, but had no effect on other lipid profiles.

RCTHighly Cited

2016·

131citations

·M. Karamali et al.

An Evaluation of a Multi‐strain Probiotic Supplement on General Wellness in Healthy Adults: A Randomized, Double‐Blind, Dose‐Response Study

The multi-strain probiotic formulation is well tolerated by healthy adults at doses of 5 billion and 25 billion CFU per day, without affecting general wellness or gastrointestinal symptoms.

RCT

2017·

0citations

·Asmaa Fatani et al.

The effect of multistrain probiotic supplementation in two doses on iron metabolism in obese postmenopausal women: a randomized trial.

Multistrain probiotic supplementation at two doses may influence iron metabolism in obese postmenopausal female patients, with hair iron content correlated to serum iron levels.

RCT

2019·

29citations

·K. Skrypnik et al.

The Health Effects of Vitamin D and Probiotic Co-Supplementation: A Systematic Review of Randomized Controlled Trials

Co-supplementation with vitamin D and probiotics provides greater health benefits than either supplement alone, including decreased disease severity, improved mental health, metabolic parameters, and reduced healthcare use.

Systematic ReviewVery Rigorous Journal

2020·

30citations

·M. Abboud et al.

Dietary supplementation with probiotics increases growth performance, improves the intestinal mucosal barrier and activates the Wnt/β-catenin pathway activity in chicks.

Dietary supplementation with compound probiotics (CPP) improves growth performance, reduces diarrhea, and enhances immune function in chicks by activating Wnt/-catenin signaling.

RCT

2023·

10citations

·Di-qing Tong et al.

The Efficacy of Lactobacillus-Containing Probiotic Supplementation in Hemodialysis Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.

High-dose multistrain lactobaccillus probiotic supplementation over 6 months did not significantly decrease markers of insulin resistance, cholesterol-triglyceride ratio, or inflammation, except for indoxyl sulfate levels in hemodialysis patients.

RCT

2020·

17citations

·P. Lim et al.

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