6 papers analyzed
Some studies suggest that prior SARS-CoV-2 infection and high antibody titers can provide protection against Omicron, while other studies indicate that primary infection with earlier strains may not be cross-protective against Omicron.
The relationship between antibody titers and SARS-CoV-2 infection, particularly during the Omicron strain epidemic period, is a critical area of research. Understanding how antibody levels correlate with protection against infection can inform public health strategies and vaccination policies.
Higher Neutralizing Antibody Levels Post-Infection and Vaccination:
Antibody Levels as Correlates of Protection:
Reduced Sensitivity of Antibody Assays for Omicron:
Limited Cross-Protection from Wild-Type Infection:
Immune Imprinting and Neutralizing Activity:
Antibody Levels and Breakthrough Infections:
The research indicates that higher antibody titers, particularly following a combination of infection and vaccination, provide better protection against the Omicron variant. However, the effectiveness of commercial antibody assays is reduced for Omicron, and primary infection with earlier strains offers limited cross-protection. Immune imprinting with the ancestral strain followed by vaccination can enhance neutralizing activity against Omicron sublineages. Overall, maintaining high antibody levels through vaccination and possibly booster doses is crucial for reducing the risk of infection during the Omicron epidemic period.
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