Sertraline headache

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Sertraline and Headache: Efficacy and Side Effects

Sertraline in Chronic Tension-Type Headache (CTTH)

Efficacy of Sertraline in CTTH

Sertraline, a selective serotonin reuptake inhibitor (SSRI), has been studied for its effects on chronic tension-type headache (CTTH). In a double-blind, placebo-controlled randomized trial involving 50 patients, sertraline significantly reduced the mean analgesic intake per week from 4.34 to 1.07 tablets, while the placebo group showed no significant reduction . However, the reduction in headache index and frequency was not significant in the sertraline group . Another study compared sertraline with amitriptyline in non-depressed CTTH patients and found that both drugs reduced headache symptoms and analgesic consumption, but amitriptyline was more effective than sertraline .

Side Effects of Sertraline in CTTH

The side effects of sertraline in the treatment of CTTH included nausea, nervousness, and dizziness, affecting 24.4% of patients . In comparison, sertraline had a more favorable side effect profile than amitriptyline, which is known for its anticholinergic side effects .

Sertraline and Headache in Depression Treatment

Comparative Studies with Other Antidepressants

Sertraline has been compared with other antidepressants like dothiepin, venlafaxine, and fluoxetine in the treatment of major depressive disorder. In these studies, headache was a common side effect across different treatment groups. For instance, in a study comparing sertraline and dothiepin, headache was frequently reported in both groups . Similarly, in a comparison between sertraline and venlafaxine, headache was one of the most common adverse events for both medications . Another study comparing sertraline and fluoxetine also reported headache as a frequent side effect .

Sertraline and Phenytoin Interaction

A study assessing the interaction between sertraline and phenytoin found that high doses of sertraline did not affect the pharmacokinetics or pharmacodynamics of phenytoin. However, headache was reported as a treatment-related side effect in both the sertraline and placebo groups .

Conclusion

Sertraline shows potential in reducing analgesic intake in patients with chronic tension-type headache, although its efficacy in reducing headache frequency and severity is less clear. When used for treating major depressive disorder, headache is a common side effect of sertraline, similar to other antidepressants. Despite its side effects, sertraline remains a viable option, especially for patients who cannot tolerate tricyclic antidepressants like amitriptyline.

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Most relevant research papers on this topic

Sertraline in chronic tension-type headache.

Sertraline significantly reduces analgesic intake per week in chronic tension-type headache patients, making it a useful alternative to amitryptiline for those who fail to respond or cannot tolerate it.

RCT

2002·

35citations

·N. N. Singh et al.

Sertraline versus amitriptyline in the prophylactic therapy of non-depressed chronic tension-type headache patients

Amitriptyline is more effective than sertraline in reducing headache symptoms and analgesic drug consumption in non-depressed chronic tension-type headache patients.

RCT

2003·

21citations

·C. Boz et al.

A double‐blind, placebo‐controlled comparison of sertraline and dothiepin in the treatment of major depression in general practice

Sertraline shows a clear advantage over placebo in treating severe major depression, while dothiepin shows no significant difference from placebo in any analyses.

RCT

1994·

36citations

·D. Doogan et al.

Randomized, double-blind comparison of venlafaxine and sertraline in outpatients with major depressive disorder. Venlafaxine 631 Study Group.

Venlafaxine is more effective in achieving remission in patients with major depressive disorder compared to sertraline, with a higher remission rate.

RCT

2000·

32citations

·O. Mehtonen et al.

A double-blind multicenter trial comparing sertraline and fluoxetine in outpatients with major depression.

Sertraline and fluoxetine are equally effective and well-tolerated in patients with major depression and associated anxiety.

RCTHighly Cited

1995·

105citations

·Bennie Eh et al.

Absence of effect of sertraline on the pharmacokinetics and pharmacodynamics of phenytoin.

High doses of setraline did not affect the pharmacokinetics or pharmacodynamics of phenytoin in healthy volunteers.

RCT

1996·

37citations

·W. Rapeport et al.

A double-blind placebo-controlled multicentre study of sertraline in the acute and continuation treatment of major depression

Sertraline is a significantly more effective antidepressant than placebo, particularly in severe depression, but has more common side effects.

RCTLarge Human Trial

1997·

25citations

·J. Olié et al.

Sexual Dysfunction Associated with the Treatment of Depression: A Placebo-Controlled Comparison of Bupropion Sustained Release and Sertraline Treatment

Bupropion SR effectively relieves depression, while sertraline is more often associated with sexual dysfunction.

RCTLarge Human TrialHighly Cited

1999·

122citations

·Charles C. Coleman et al.

A placebo-controlled comparison of the antidepressant efficacy and effects on sexual functioning of sustained-release bupropion and sertraline.

Bupropion SR and sertraline are both effective in treating depression, but sertraline is more often associated with sexual dysfunction and other adverse events.

RCTLarge Human TrialHighly Cited

1999·

242citations

·H. Croft et al.

Sertraline: a review of its use in the management of major depressive disorder in elderly patients.

Sertraline is an effective and well-tolerated antidepressant for elderly patients with major depressive disorder, offering benefits over nortriptyline and fluoxetine without affecting antidepressant effects.

Literature Review

2002·

41citations

·R. B. Muijsers et al.

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