Side effects from atenolol
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10 papers analyzed
These studies suggest that atenolol can cause skin rash, drug-induced connective tissue disease, and rare acute psychotic behavior, while it is less likely to cause sedation, drowsiness, or significant central nervous system side effects.
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Side Effects of Atenolol: A Comprehensive Overview
Psychological Side Effects of Atenolol
Atenolol, a beta-blocker commonly used to treat hypertension, has been associated with various psychological side effects. Studies have shown that atenolol can significantly reduce arousal over a six-week period, although it does not appear to affect anxiety levels. Additionally, while some beta-blockers are known for causing vivid dreams, hallucinations, and sleep disturbances, atenolol has been found to have fewer central nervous system (CNS) side effects compared to more lipophilic beta-blockers like metoprolol . However, there have been rare reports of acute psychotic behavior associated with atenolol, including vivid dreams, nightmares, and short-term memory lapses.
Sleep Disturbances and Fatigue
Sleep disturbances are a notable side effect of many beta-blockers. In a comparative study, atenolol was found to decrease sleep disturbances over time, unlike pindolol, which increased them. This reduction in sleep disturbances with atenolol may be attributed to its lower lipophilicity, which limits its penetration into the CNS. Additionally, patients on atenolol reported a reduction in fatigue over the course of treatment.
Dermatological Reactions
Atenolol has been linked to rare but significant dermatological reactions, including psoriasiform skin eruptions, skin necrosis, and vasculitis. In some cases, atenolol has been associated with drug-induced lupus erythematosus, characterized by the appearance of skin rashes and the presence of antihistone antibodies. These symptoms typically subside upon discontinuation of the drug.
Cardiovascular and Hematological Effects
Atenolol is effective in reducing both systolic and diastolic blood pressure, making it a potent antihypertensive agent . However, it has also been observed to reduce plasma high-density lipoprotein (HDL) cholesterol levels, which could have implications for long-term cardiovascular health. Despite these changes, blood chemistry and other hematological parameters generally remain unaffected.
CNS-Related Side Effects
While atenolol is generally associated with fewer CNS side effects compared to other beta-blockers, some patients have reported issues such as sleep disturbances and restless nights when switching from more lipophilic beta-blockers . However, these side effects are significantly less frequent and severe with atenolol compared to other beta-blockers like metoprolol.
Conclusion
Atenolol is a widely used beta-blocker with a relatively favorable side effect profile, particularly in terms of CNS-related issues and sleep disturbances. While it can cause rare but serious dermatological reactions and has some impact on lipid profiles, its overall efficacy in managing hypertension makes it a valuable therapeutic option. Patients should be monitored for any adverse effects, particularly those related to psychological and dermatological health, to ensure safe and effective use of the medication.
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