Side effects of diflucan
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Side Effects of Diflucan (Fluconazole)
Overview of Diflucan (Fluconazole)
Diflucan, also known by its generic name fluconazole, is a widely used antifungal medication. It is particularly effective in treating various forms of candidiasis, including vaginal, oropharyngeal, esophageal, and systemic infections, as well as urinary tract infections, peritonitis, and cryptococcal meningitis. It is also used as a prophylactic treatment for bone marrow transplant recipients .
Common Side Effects of Diflucan
Gastrointestinal Disturbances
One of the most frequently reported side effects of Diflucan is gastrointestinal disturbances. These can include symptoms such as nausea, vomiting, abdominal pain, and diarrhea. These side effects are generally mild to moderate in nature and are among the most common complaints from patients using this medication .
Headaches
Headaches are another common side effect associated with Diflucan. Similar to gastrointestinal issues, these headaches are typically mild to moderate and do not usually require discontinuation of the medication .
Drug Interactions and Contraindications
Drug Interactions
Diflucan is known to interact with several other medications, which can lead to significant clinical implications. For instance, it can potentiate the effects of oral hypoglycemic agents, potentially causing symptomatic hypoglycemia in patients. Additionally, it increases the prothrombin time in patients taking oral anticoagulants, which can increase the risk of bleeding .
Contraindications
Diflucan is contraindicated in patients who are taking cisapride and terfenadine due to the risk of serious cardiac events. Patients on these medications should avoid using Diflucan to prevent potentially life-threatening interactions .
Rare and Severe Side Effects
While the side-effect profile of Diflucan is generally minimal, there are rare instances of severe adverse reactions. These can include severe allergic reactions, liver toxicity, and QT prolongation, which can lead to serious cardiac arrhythmias. However, such severe side effects are uncommon and typically occur in patients with predisposing conditions or those taking other interacting medications .
Conclusion
Diflucan (fluconazole) is a highly effective antifungal medication with a relatively mild side-effect profile. Common side effects include gastrointestinal disturbances and headaches, while more severe reactions are rare. Patients should be aware of potential drug interactions and contraindications, particularly with medications like cisapride and terfenadine. Overall, Diflucan remains a valuable option for treating various fungal infections due to its efficacy and ease of use 13.
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