Side effects of lisinopril and amlodipine taken together

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Side Effects of Lisinopril and Amlodipine Taken Together

Introduction to Lisinopril and Amlodipine Combination Therapy

Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, and amlodipine, a calcium channel blocker, are commonly prescribed together to manage hypertension. This combination is known for its efficacy in reducing blood pressure more effectively than either drug alone 12. However, like all medications, this combination can have side effects.

Common Side Effects of Lisinopril and Amlodipine

General Adverse Effects

The combination of lisinopril and amlodipine has been associated with several common side effects. These include cough, ankle edema, and dizziness. In a comparative study, it was found that the combination of amlodipine with lisinopril resulted in a higher incidence of these side effects compared to the combination of amlodipine with losartan . Specifically, cough and ankle edema were more frequently reported in patients taking the lisinopril and amlodipine combination .

Cardiovascular and Metabolic Effects

Patients treated with the combination of amlodipine and lisinopril have shown significant reductions in blood pressure, both at peak and trough levels, indicating a potent and sustained antihypertensive effect . However, this combination can also lead to changes in lipid and carbohydrate metabolism, which may affect patients with comorbid conditions like obesity .

Comparative Adverse Effects

Lisinopril vs. Losartan Combinations

When comparing the adverse effects of amlodipine combined with lisinopril versus amlodipine combined with losartan, the latter combination was found to have fewer side effects. Patients on the amlodipine and losartan combination reported better control of blood pressure and fewer incidences of cough and ankle edema . This suggests that while the lisinopril and amlodipine combination is effective, it may not be the best option for all patients due to its side effect profile.

Ethnic Variations in Response

The response to lisinopril and amlodipine can vary based on ethnicity. For instance, Black patients tend not to respond as well to lisinopril monotherapy compared to Caucasian patients, although they respond similarly to the combination therapy . This highlights the importance of considering patient demographics when prescribing this combination.

Conclusion

The combination of lisinopril and amlodipine is effective in managing hypertension, offering significant blood pressure reductions. However, it is associated with side effects such as cough, ankle edema, and dizziness. Comparative studies suggest that alternative combinations, like amlodipine with losartan, may offer similar efficacy with fewer adverse effects. Additionally, patient demographics, such as ethnicity, can influence the response to this combination therapy. Therefore, healthcare providers should carefully consider these factors when prescribing lisinopril and amlodipine together.

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Most relevant research papers on this topic

The Curative Effect of Amlodipine and Lisinopril on Hypertension

Amlodipine combined with lisinopril effectively reduces blood pressure and may reduce left ventricular remodeling in patients with hypertension, with fewer adverse effects.

RCT

2010·

0citations

·Wang Zhan-xin

Amlodipine and lisinopril in combination for the treatment of essential hypertension: efficacy and predictors of response

Amlodipine and lisinopril in combination significantly lower blood pressure, with Black patients showing less response to lisinopril monotherapy but similar response to the combination.

RCT

1993·

56citations

·F. Cappuccio et al.

Comparative Study of Adverse Effect of Amlodipine with Lisinopril and Amlodipine with Losartan in Control of Blood Pressure

Amlodipine with Losartan combination is better than Amlodipine with Lisinopril combination for controlling blood pressure due to lesser adverse effects like cough and ankle edema.

Observational Study

2017·

0citations

·S. Javed

EFFECTS OF THE COMBINATIONS OF AMLODIPINE WITH AN LISINOPRIL OR A CARVEDILOL IN PATIENTS WITH ARTERIAL HYPERTENSION AND OBESITY

Combinations of Amlodipine/ Lisinopril and Amlodipine/ Carvedilol improve blood pressure, hypertensive reaction under isometric exercise, lipid and carbohydrate metabolism, and quality of life in patients with arterial hypertension and obesity.

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·M. Bubnova et al.

PP.07.35: EFFECTS OF LISINOPRIL/AMLODIPINE SINGLE PILL COMBINATION ON AMBULATORY BRACHIAL AND CENTRAL BLOOD PRESSURE IN HYPERTENSIVE SUBJECTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE

Lisinopril/amlodipine fixed combination effectively reduces ambulatory brachial and central blood pressure in hypertensive patients with non-alcoholic fatty liver disease, improving arterial stiffness.

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2015·

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·I. Semagina et al.

Clinical study on safety and efficacy of the administration of amlodipine in a combination with lisinopril in hypertensive patients.

Amlodipine combined with lisinopril effectively reduces blood pressure in both moderate and severe hypertensive patients, with good tolerance and minimal adverse effects.

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2005·

2citations

·A. Arslanagić et al.

Comparative renal hemodynamic effects of lisinopril, verapamil, and amlodipine in patients with chronic renal failure.

Lisinopril and verapamil effectively lower blood pressure in chronic renal disease patients, with some showing favorable renal hemodynamic responses.

Non-RCT

1993·

9citations

·P. August et al.

ARTERIAL HYPERTENSION IN THE PRESENCE OF OVERWEIGHT AND OBESITY. THE CAPABILITIES OF AMLODIPINE AND LISINOPRIL COMBINATION. Part 2. Antihypertensive and Organoprotective Effects of Amlodipine/Lisinopril Fixed-Dose Combination in Patients with Arterial Hypertension in the Presence of Overweight and O

Amlodipine and lisinopril combined effectively reduce blood pressure and protect organs in overweight patients with arterial hypertension.

2017·

1citation

·O. Ostroumova et al.

A diuretic is more effective than a beta-blocker in hypertensive patients not controlled on amlodipine and lisinopril.

In hypertensive patients not controlled on amlodipine and lisinopril, bendrofluazide 5 mg once daily significantly lowers blood pressure compared to placebo and atenolol 100 mg once daily.

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1996·

17citations

·T. Antonios et al.

Therapeutic Options for the Single Pill Combination of Lisinopril, Amlodipine and Rosuvastatin: a Systematic Review

The single pill combination of amlodipine, lisinopril, and rosuvastatin effectively reduces blood pressure and LDL-C in hypertensive patients with high or moderate risk of developing cardiovascular diseases, including those with concomitant hypercholesterolemia.

Systematic Review

2022·

1citation

·S. Gilyarevsky et al.

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