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These studies suggest confusion, anorexia, fatigue, cachexia, weight loss, dyspnea, and dysphagia are symptoms associated with advanced cancer stages.
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Research has explored the potential link between psychological factors and the survival of women with stage II breast cancer. A study involving 280 women assessed psychological symptoms using the Symptom Check List-90-Revised (SCL-90-R) before chemotherapy. The study found no significant predictive effect of psychological distress levels on disease-free or overall survival when controlling for sociodemographic and medical variables. This suggests that, in the context of potent medical factors, psychological distress may have a relatively small impact on survival outcomes.
While general psychological symptoms did not show a significant impact, other studies have indicated that specific emotional coping mechanisms, such as depression, "fighting spirit," and hostility, might have some association with survival, although these effects are relatively minor compared to medical factors. This highlights the complexity of psychological influences on cancer progression and the need for more focused research on specific emotional predictors.
A systematic review of 44 studies examined the prognostic significance of various symptoms in advanced cancer patients. Symptoms such as confusion, anorexia, fatigue, cachexia, weight loss, cognitive impairment, drowsiness, dyspnea, dysphagia, dry mouth, and depressed mood were frequently associated with survival outcomes. Specifically, confusion, anorexia, fatigue, cachexia, weight loss, dyspnea, and dysphagia were identified as independent prognostic factors in a significant portion of the studies.
The review also differentiated the prognostic value of symptoms across three stages of palliative care: disease-directed palliation, symptom-oriented palliation, and terminal stage palliation. In the disease-directed palliation stage, symptoms like anorexia, cachexia, weight loss, dysphagia, and pain were significant predictors of survival. In the symptom-oriented palliation stage, confusion, fatigue, cachexia, weight loss, dyspnea, dysphagia, and nausea were notable predictors. This underscores the importance of symptom assessment in managing advanced cancer and tailoring palliative care to improve patient outcomes.
In summary, while psychological distress does not significantly predict survival in stage II breast cancer, specific emotional coping mechanisms may have minor associations. In advanced cancer, physical symptoms such as confusion, anorexia, fatigue, cachexia, weight loss, dyspnea, and dysphagia are important prognostic factors, particularly in different stages of palliative care. These findings highlight the multifaceted nature of cancer symptoms and the need for comprehensive symptom assessment in both psychological and physical domains to optimize patient care and survival outcomes.
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