Sucralfate and omeprazole drug interaction

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Combined Use of Sucralfate and Omeprazole: Clinical Efficacy and Safety

Several studies have examined the combined use of sucralfate and omeprazole, particularly for preventing and treating upper gastrointestinal (GI) bleeding and gastritis. Research shows that using both drugs together is effective in reducing the risk of upper GI hemorrhage after serious stroke and in patients with liver cirrhosis and hepatitis B, with lower rates of rebleeding and hospitalizations compared to control groups. Importantly, these studies report no significant adverse effects or safety concerns when the drugs are used together, and patient compliance is good 124.

Sucralfate and Omeprazole: Comparative Effectiveness in Gastric Protection

When comparing the individual effects of sucralfate and omeprazole, findings are mixed and may depend on the specific condition being treated. In animal models, sucralfate has shown greater efficacy than omeprazole in reducing gastric mucosal inflammation and cell death caused by Helicobacter pylori lipopolysaccharide, likely due to its ability to suppress certain inflammatory markers more effectively . Sucralfate also demonstrated a stronger protective effect against ethanol-induced gastric lesions in rats, while omeprazole was not effective in this model . However, in clinical trials for prepyloric gastric ulcers and in equine models of NSAID-induced gastric injury, omeprazole was superior to sucralfate in healing ulcers, relieving symptoms, and preventing lesion severity 89.

Drug Interactions and Antimicrobial Activity

Regarding drug interactions, there is no evidence from the available studies of any harmful interaction between sucralfate and omeprazole when used together for GI protection. Both drugs can be safely combined, and their use does not exceed recommended dosing guidelines . Additionally, both sucralfate and omeprazole can enhance the effectiveness of antibiotics against H. pylori, with sucralfate showing a comparable effect to omeprazole in increasing the susceptibility of the bacteria to various antibiotics .

Conclusion

Current research indicates that sucralfate and omeprazole can be safely used together, with no significant drug interaction concerns. Their combined use is effective for preventing and treating upper GI bleeding and gastritis, and both drugs can enhance the action of antibiotics against H. pylori. The choice between sucralfate and omeprazole, or their combination, may depend on the specific clinical scenario, as each has strengths in different contexts. Overall, the combination is well-tolerated and beneficial for patients at risk of GI complications 12345678+1 MORE.

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Most relevant research papers on this topic

Omeprazole combined with sucralfate in preventing upper alimentary tract hemorrhage followed serious stroke

Omeprazole combined with sucralfate effectively prevents upper alimentary tract hemorrhage after serious stroke, with a significantly lower rate than cimetidine.

2003·

0citations

·Xiao Ying-xiu

The Analysis of Clinical Effect of Omeprazole Combined with Sucralfate in Treatment of Acute Hemorrhagic Gastritis

Omeprazole combined with sucralfate effectively treats acute hemorrhagic gastritis, with a remarkable clinical effect and high safety, warranting further promotion.

RCT

2013·

0citations

·Huang Lu

Up-regulation of endothelin-1 in gastric mucosal inflammatory responses to Helicobacter pylori Lipopolysaccharide: effect of omeprazole and sucralfate.

Omeprazole reduces mucosal inflammation caused by H. pylori lipopolysaccharide, while sucralfate significantly reduces inflammation, both in a rat model of acute gastritis.

Non-RCTAnimal Study

2000·

8citations

·B. Slomiany et al.

Omeprazole combined with sucralfate on the prevention of upper gastrointestinal rebleeding in the cirrhosis with hepatitis B

Omeprazole combined with sucralfate effectively prevents upper gastrointestinal rebleeding in liver cirrhosis with hepatitis B, reducing the number of inpatients and reoccurring episodes.

RCT

2011·

0citations

·Zhang Zhao-ya

Protective effects of sucralfate and omeprazole on gastric mucosal damage induced by ethanol in rats.

Sucralfate effectively prevents gastric lesions induced by ethanol, while omeprazole has no protective effect.

1998·

7citations

·N. Kaya et al.

Sucralfate affects the susceptibility of Helicobacter pylori to antimicrobial agents.

Sucralfate enhances the anti-H. pylori activity of antibiotics, with a comparable effect to omeprazole, making it a potential addition to anti-ulcer drugs.

In Vitro Study

1995·

12citations

·B. Slomiany et al.

Evaluation of Prescription of Cases of Gerd Acid Disorders in Patients at Kasatria Public Health Center, Pematang Siantar City

Combination therapy is often used for stomach acid disorders, with antacids, ranitidine, and sucralfate being the most common drugs used.

2022·

0citations

·Beta Hanindiya et al.

Effect of omeprazole and sucralfate on prepyloric gastric ulcer. A double blind comparative trial and one year follow up.

Omeprazole has a higher healing rate and more pronounced symptom relief than sucralfate, with more patients in remission after a one-year follow-up period.

RCT

1994·

4citations

·Toft S0rensen et al.

Effect of omeprazole and sucralfate on gastrointestinal injury in a fasting/NSAID model.

Omeprazole is superior to sucralfate in mitigating gastric lesion severity in healthy horses exposed to a feed-fast/NSAID model.

2021·

9citations

·R. Bishop et al.

Occurrence of ventilator-associated pneumonia in mechanically ventilated pediatric intensive care patients during stress ulcer prophylaxis with sucralfate, ranitidine, and omeprazole.

No significant difference in ventilator-associated pneumonia incidence or mortality was found between sucralfate, ranitidine, or omeprazole treatment regimens for pediatric intensive care patients.

RCTHighly Cited

2002·

95citations

·D. Yıldızdaş et al.

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