Sudden alcohol intolerance

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Sudden Alcohol Intolerance: Causes and Implications

Alcohol Intolerance and Aspirin-Exacerbated Respiratory Disease (AERD)

AERD and Alcohol Intolerance Correlation
Research indicates a significant correlation between alcohol intolerance and aspirin-exacerbated respiratory disease (AERD). A systematic review of studies from 1968 to 2022 found that 52.8% of AERD patients reported sinopulmonary exacerbations after alcohol intake . This suggests that individuals with AERD are at a higher risk of experiencing alcohol intolerance.

Impact of Medical Therapy on Alcohol Tolerance
Interestingly, medical interventions such as aspirin desensitization have shown potential in improving alcohol tolerance among AERD patients. One of the reviewed studies noted an improvement in alcohol tolerance following such treatments . This highlights the possibility of mitigating alcohol intolerance symptoms through targeted medical therapies.

Alcohol Intolerance in Hypereosinophilic Syndrome

Initial Symptom in Hypereosinophilic Syndrome
Alcohol intolerance can also be an initial symptom in patients with hypereosinophilic syndrome. In documented cases, one patient experienced persistent alcohol intolerance throughout the disease course, while another saw a resolution of symptoms, including alcohol intolerance, after treatment with prednisolone and vincristine . This suggests that alcohol intolerance in hypereosinophilic syndrome may be influenced by the underlying hypereosinophilia and could serve as a clinical marker for disease activity.

Behavioral Implications of Alcohol Intolerance

Impulse Control Development
An experimental study on alcohol intolerance among Han Chinese males revealed that those intolerant to alcohol exhibited better impulse control in other behavioral domains compared to their alcohol-tolerant counterparts . This finding supports the strength model of self-control, suggesting that routine behaviors requiring self-control, such as resisting alcohol, can enhance overall impulse control. This improved impulse control can have broad implications for health, education, and socioeconomic outcomes.

Conclusion

Sudden alcohol intolerance can be associated with various medical conditions such as AERD and hypereosinophilic syndrome. Understanding these associations is crucial for diagnosing and managing the underlying conditions. Additionally, alcohol intolerance may have broader behavioral implications, potentially enhancing impulse control in other areas of life. Further research and targeted medical therapies could provide more insights and improve management strategies for those affected by sudden alcohol intolerance.

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Most relevant research papers on this topic

Relationship Between Alcohol Intolerance and Aspirin-Exacerbated Respiratory Disease (AERD): Systematic Review.

Patients with aspirin-exacerbated respiratory disease (AERD) have a high risk of alcohol intolerance, and aspirin desensitization may improve alcohol tolerance in this patient population.

Systematic Review

2023·

2citations

·E. Candelo et al.

Alcohol intolerance in the hypereosinophilic syndrome.

Alcohol intolerance may be influenced by hypereosinophilia and may help evaluate the activity of the malignant disorder.

Case Report

1988·

5citations

·Jolanta Lederman et al.

An experimental analysis of acquired impulse control among adult humans intolerant to alcohol

Alcohol intolerance in adult males leads to improved impulse control in other behavioral domains, with benefits across various behavioral domains.

Non-RCT

2017·

67citations

·Jianxin Wang et al.

Anxiety sensitivity, distress tolerance, and discomfort intolerance in relation to coping and conformity motives for alcohol use and alcohol use problems among young adult drinkers.

Distress tolerance and anxiety sensitivity are significantly related to coping motives for alcohol use, while discomfort intolerance and anxiety sensitivity predict alcohol use problems in young adult drinkers.

Observational StudyHighly Cited

2010·

163citations

·Ashley N Howell et al.

Mechanism and significance of carbohydrate intolerance in chronic alcoholism.

Chronic alcoholism is dabetogenic in susceptible individuals, with transient carbohydrate intolerance being an early step in the development of adult-onset diabetes.

Non-RCT

1978·

31citations

·G. Sereny et al.

Alcoholic diabetes. Induction of glucose intolerance with alcohol.

Alcohol consumption can induce glucose intolerance, with the effect being associated with increased insulin response and delayed peak insulin concentration, not caloric value or increased secretion of glucocorticoid or growth hormone.

Case ReportHighly Cited

1971·

103citations

·G. B. Phillips et al.

Alcohol withdrawal syndrome: mechanisms, manifestations, and management

Alcohol withdrawal syndrome (AWS) can cause early clinical manifestations in neurological patients, but diagnosis and treatment often delay until dramatic symptoms occur.

Highly Cited

2016·

172citations

·S. Jesse et al.

Implicit measures of alcohol approach and drinking identity in alcohol use disorder: A preregistered double‐blind randomized trial with cathodal transcranial direct current stimulation (tDCS)

Cathodal tDCS does not alter implicit associations with alcohol in abstinent alcohol use disorder patients, indicating no effect of neuromodulation on these associations.

RCTRigorous Journal

2022·

1citation

·T. Schwippel et al.

Alcohol-Induced Sudden Cardiac Death in a Teenager With PPA2 Gene Mutations.

A 19-year-old female with alcohol intolerance died unexpectedly after consuming minimal alcohol, revealing PPA2 gene mutations, which may cause sudden cardiac death when combined with alcohol.

Case Report

2023·

2citations

·Sydney Graham et al.

Moderators of sudden gains after sessions addressing emotion regulation among women in treatment for alcohol use.

Women with high levels of depression and/or anxiety and low confidence to remain abstinent in a negative emotional state are more likely to experience sudden gains in alcohol use disorder treatment.

2017·

9citations

·C. G. Holzhauer et al.

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