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These studies suggest that sudden severe headaches can have numerous causes, including benign conditions, subarachnoid haemorrhage, viral infections, reversible cerebral vasoconstriction syndrome, and pituitary apoplexy, and require thorough investigation to rule out life-threatening conditions.
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Sudden severe headache, often referred to as thunderclap headache (TCH), is characterized by an abrupt onset of intense pain that reaches its peak within minutes. This type of headache can be alarming and may indicate serious underlying conditions, including life-threatening ones such as subarachnoid hemorrhage (SAH) .
SAH is one of the most critical causes of sudden severe headache. It occurs due to bleeding in the space surrounding the brain, often from a ruptured aneurysm. Approximately 11.3% of patients presenting with TCH are diagnosed with SAH. Symptoms such as nausea, neck stiffness, and impaired consciousness are more frequent in SAH cases, although these symptoms are not exclusive to SAH .
RCVS is another significant cause of TCH, characterized by recurrent episodes of severe headache due to temporary narrowing of the cerebral arteries. It accounts for a substantial proportion of TCH cases and is often triggered by activities such as bathing. Unlike SAH, RCVS typically has a benign course but requires thorough investigation to confirm the diagnosis.
There are over 100 different causes of sudden severe headache, including primary headaches, cerebral infarction, intracerebral hematoma, aseptic meningitis, and sinus thrombosis . Less common causes include conditions like pneumocephalus and pituitary apoplexy, which can present with similar symptoms but require different management strategies .
The initial assessment of a patient with sudden severe headache should include a detailed history and physical examination. Key features to note are the onset, intensity, and associated symptoms such as vomiting, visual disturbances, and neurological deficits .
Computed tomography (CT) scans are highly effective in detecting SAH and are often the first line of investigation. If the CT scan is negative but clinical suspicion remains high, a lumbar puncture may be performed to check for the presence of blood in the cerebrospinal fluid, which can indicate SAH or other conditions like meningitis .
In cases where initial tests are inconclusive, magnetic resonance imaging (MRI) with angiography can be used to identify other potential causes such as RCVS or pituitary apoplexy. This approach helps in ruling out structural abnormalities and confirming diagnoses that might not be evident on a CT scan.
For patients presenting with symptoms suggestive of SAH, immediate medical intervention is crucial. This may include surgical procedures to repair aneurysms and prevent re-bleeding. In cases of RCVS, management typically involves the use of calcium channel blockers to alleviate vasoconstriction.
Patient involvement in decision-making is essential, especially when considering additional tests or treatments. Shared decision-making helps in addressing patient concerns and preferences, particularly regarding invasive procedures like lumbar puncture. Follow-up care is important to monitor for recurrence and manage any long-term complications.
Sudden severe headache is a symptom that warrants prompt and thorough evaluation due to its potential to indicate serious underlying conditions. While SAH remains a critical concern, other causes such as RCVS and primary headaches are also significant. Accurate diagnosis through appropriate imaging and patient-centered care are key to effective management and improved patient outcomes.
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