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These studies suggest that symptoms of undiagnosed diabetes can include oral symptoms, nephropathy, peripheral neuropathy, and cognitive impairment, with a higher risk of cardiovascular disease and a need for improved education and early detection.
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Undiagnosed non-insulin dependent diabetes mellitus (NIDD) often presents with various oral symptoms. A study involving 43 patients revealed that 16 experienced burning mouth syndrome, while 10 had prolonged fungal and/or bacterial infections. Additionally, nine patients reported altered taste, six had oral mucosal lesions such as erosive lichen planus, and isolated cases of sialosis and sialorrhoea were also noted. Importantly, improving glycemic control led to the resolution of these oral symptoms in most cases.
In a study conducted in New Zealand, six cardinal symptoms of hyperglycemia were identified among people without known diabetes. These symptoms included increased thirst, weight loss, frequent urination (polyuria), boils, tiredness, and blurred vision. These symptoms were prevalent across different ethnic groups, highlighting the importance of awareness and screening in diverse populations.
Depressive symptoms are more common in individuals with diagnosed diabetes compared to those with undiagnosed diabetes. A study found that diagnosed diabetes was associated with a higher risk of depressive symptoms, whereas undiagnosed diabetes did not show a significant association with depression. Additionally, undiagnosed cognitive impairment in patients with type 2 diabetes is linked to reduced health status and increased depressive symptoms, indicating the need for early detection and tailored care.
Undiagnosed diabetes can lead to significant complications such as nephropathy and peripheral neuropathy. Research indicates that 26.5% of individuals with undiagnosed diabetes showed signs of nephropathy, and 21.5% had peripheral neuropathy. These complications were comparable to those found in diagnosed diabetes, underscoring the importance of early screening and intervention.
Among elderly individuals, undiagnosed diabetes and impaired glucose tolerance (IGT) did not predict poorer self-perceived health or a higher number of symptoms compared to non-diabetic status. This suggests that undiagnosed diabetes in older adults may not be easily detectable based on self-perceived health alone.
Undiagnosed diabetes is prevalent among younger adults and is associated with a higher cardiometabolic risk profile compared to diagnosed diabetes. Younger adults with undiagnosed diabetes are more likely to have uncontrolled hypertension, hyper-low-density lipoprotein cholesterolemia, and a higher predicted risk for cardiovascular disease. This highlights the need for intensive screening and public health initiatives targeting younger populations.
Many patients with undiagnosed diabetes are unaware of the relevance of their symptoms. Interviews with recently diagnosed patients revealed that diagnoses were often serendipitous or symptom-driven, with none resulting from physician-initiated screening. This indicates a need for better education and awareness among individuals at risk for diabetes to facilitate earlier detection and diagnosis.
Undiagnosed diabetes presents with a variety of symptoms, including oral manifestations, common hyperglycemic symptoms, depressive symptoms, and complications like nephropathy and peripheral neuropathy. Awareness and early screening are crucial, especially in younger adults and diverse populations, to prevent complications and improve health outcomes. Enhanced education and vigilance among healthcare providers can aid in the timely diagnosis and management of diabetes.
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