Topical magnesium safety
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Topical Magnesium Safety in Clinical and Dermatological Use
Safety Profile of Topical Magnesium in Wound Healing and Dermatology
Multiple studies have shown that topical magnesium preparations are generally safe for use on the skin. In a randomized controlled trial involving obstetric and gynecologic patients, the application of magnesium hydroxide ointment (in combination with zinc chloride spray) for incisional wound healing resulted in no reported side effects, indicating a favorable safety profile in this context . Similarly, a pilot study using magnesium microneedle patches for acne treatment found no adverse reactions among participants, further supporting the safety of topical magnesium in dermatological applications .
Topical Magnesium for Postoperative Sore Throat: Safety and Tolerability
Systematic reviews and meta-analyses evaluating the use of topical magnesium (such as magnesium sulfate sprays or gargles) to prevent postoperative sore throat have consistently reported that the intervention is not associated with significant adverse events. Across several randomized controlled trials, no significant side effects were observed, and the treatment was well tolerated by adult surgical patients 236. These findings suggest that topical magnesium is a safe option for reducing the incidence and severity of postoperative sore throat.
Topical Magnesium in Hypomagnesaemia Management: Safety in Special Populations
Pilot studies investigating the use of topical magnesium chloride sprays in patients with ileostomy and chronic hypomagnesaemia have demonstrated that the treatment is generally safe. In these studies, patients applied magnesium sprays twice daily for several weeks, and no serious adverse effects were reported. Some patients experienced improvements in muscle cramping, and serum magnesium levels were maintained or increased without any significant drops or negative outcomes 58.
Effects on Skin Barrier and Absorption
Research into the effects of topical magnesium on skin integrity and barrier function has shown that magnesium ions can penetrate the stratum corneum, especially at higher concentrations and with longer exposure times. While magnesium treatment can increase skin hydration, it does not negatively affect transepidermal water loss or skin pH, and no harmful effects on skin physiology have been observed in healthy volunteers . This further supports the safety of topical magnesium for routine use.
Conclusion
The available evidence from clinical trials, systematic reviews, and pilot studies indicates that topical magnesium preparations are safe for use in wound healing, dermatological applications, prevention of postoperative sore throat, and management of hypomagnesaemia in special populations. Across diverse patient groups and application methods, no significant adverse effects have been reported, making topical magnesium a well-tolerated and safe therapeutic option.
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