Tribulus terrestris dosage in clinical studies
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Tribulus terrestris Dosage in Clinical Studies: Human and Animal Research
Clinical Dosage Regimens in Human Studies
Several clinical studies have explored the effects of Tribulus terrestris (TT) in both men and women, using a range of dosages and treatment durations. In women with sexual dysfunction, two dosage regimens were compared: 94 mg three times daily (total 282 mg/day) and 280 mg once daily, both for 90 days. Both regimens led to improvements in sexual function, with no significant side effects reported, suggesting that both lower and higher daily doses can be effective and safe in this population .
In men, systematic reviews and clinical trials have reported TT supplementation at doses ranging from 400 mg to 750 mg per day, typically administered for 1 to 3 months. These studies found that TT at these dosages may improve erectile dysfunction in some cases, but most did not observe significant changes in testosterone levels unless the subjects had low baseline androgen levels . One clinical trial specifically used 750 mg/day (250 mg three times daily) for 3 months in aging males with partial androgen deficiency, reporting significant improvements in testosterone levels and erectile function . Another trial in men with mild to moderate erectile dysfunction used 750 mg/day (administered as 3 × 2 tablets of 250 mg each) for 12 weeks, showing significant improvement in sexual function compared to placebo, with good tolerability .
However, a study in men with unexplained infertility using 750 mg/day for 3 months found no significant changes in testosterone or semen parameters, indicating that the efficacy of TT may depend on the underlying condition being treated .
Dosage in Animal Studies
Animal studies have used a wide range of TT dosages, often higher relative to body weight compared to human studies. For example, nephroprotective and antioxidant effects were observed in rats at 250 mg/kg and 500 mg/kg per day, with the higher dose showing greater efficacy . In reproductive studies, doses of 10 mg/kg/day for 8 weeks increased primary spermatocyte numbers in rats, while lower doses did not have a significant effect . Other studies used 250 mg/kg/day in rats for 28 days to protect against chemotherapy-induced reproductive damage, and 11 mg/kg/day in mice for 14 days to protect against cyclophosphamide-induced toxicity 810. In cytogenetic studies, 300 mg/kg and 600 mg/kg per day for 4 weeks were used to assess protective effects against drug-induced cytotoxicity .
Summary of Dosage Ranges
- Human studies: 282–750 mg/day, typically for 1–3 months, divided into one to three daily doses 12359.
- Animal studies: 10–600 mg/kg/day, with higher doses generally showing greater efficacy in protective and reproductive outcomes 467810.
Conclusion
Clinical studies of Tribulus terrestris most commonly use daily doses between 282 mg and 750 mg, administered for periods of 1 to 3 months, with both divided and single daily dosing regimens showing efficacy and safety in various populations. Animal studies use much higher doses relative to body weight, often to explore protective or reproductive effects. The optimal dosage may depend on the specific health condition and population, with higher doses not always resulting in greater benefits in all outcomes.
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