Undenatured type 2 collagen
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The Role of Undenatured Type II Collagen in Osteoarthritis and Joint Health
Introduction to Undenatured Type II Collagen
Undenatured type II collagen (UC-II) is a form of collagen that retains its natural structure and is derived from chicken sternum. It has gained attention for its potential benefits in managing osteoarthritis (OA) and improving joint health. This article synthesizes recent research findings on the efficacy of UC-II in treating OA and supporting joint function.
UC-II and Osteoarthritis Management
Efficacy in Osteoarthritis Patients
Several studies have demonstrated the effectiveness of UC-II in managing osteoarthritis symptoms. In a study involving patients with type 2 diabetes mellitus (T2DM) and knee OA, UC-II significantly improved motor functions, reduced pain, stiffness, and physical dysfunction, and enhanced knee flexion range after a three-month intervention . Another study on women aged 60 to 80 years with knee OA found that UC-II supplementation for 90 days significantly improved pain, joint stiffness, and quality of life in the physical domain .
Mechanisms of Action
UC-II appears to exert its effects through multiple mechanisms. It reduces inflammation by decreasing levels of inflammatory cytokines such as IL-6 and increasing anti-inflammatory cytokines like IL-10 13. Additionally, UC-II helps in maintaining cartilage integrity by lowering the levels of matrix metalloproteinases (MMPs), which are enzymes that degrade cartilage .
UC-II in Animal Models
Benefits in Dogs
Research on dogs has shown that UC-II can mitigate inflammation and cartilage degeneration caused by exercise. In healthy Labrador Retrievers, UC-II supplementation resulted in lower levels of inflammatory markers and cartilage degeneration markers post-exercise compared to a placebo group 34. This suggests that UC-II can be beneficial not only for dogs with OA but also for healthy dogs undergoing intense physical activity.
Combined Use with Other Supplements
A scoping review highlighted the combined use of UC-II and Boswellia serrata, another anti-inflammatory supplement, in managing OA in dogs. The combination was found to improve general clinical state, reduce lameness, and enhance mobility, making it a valid option for long-term OA management .
UC-II in Healthy Individuals
Joint Support and Pain Reduction
UC-II has also been studied in healthy individuals who experience joint discomfort due to strenuous exercise. A randomized, double-blind, placebo-controlled study found that UC-II supplementation improved knee joint extension and allowed participants to exercise longer before experiencing joint pain. The study concluded that UC-II is effective in moderating joint function and pain in healthy subjects .
Gastrointestinal Digestion and Bioavailability
The structural integrity of UC-II during gastrointestinal digestion is crucial for its efficacy. Studies have shown that UC-II maintains its triple helix structure under various pH conditions, which is essential for its activity in relieving arthritis. Pepsin-soluble UC-II (SC II) was found to be more effective in maintaining its structure and bioavailability compared to natural insoluble UC-II (IC II) .
Conclusion
Undenatured type II collagen (UC-II) has shown promising results in managing osteoarthritis and supporting joint health in both humans and animals. Its ability to reduce inflammation, maintain cartilage integrity, and improve joint function makes it a valuable supplement for individuals with OA and those engaged in strenuous physical activities. Further research is warranted to fully understand its long-term benefits and potential preventive effects.
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