Vitamin b2

Pro Research Analysisby

Searched over 200M research papers for "vitamin b2"

Analyzed relevant papers

The Role and Benefits of Vitamin B2 (Riboflavin)

Introduction to Vitamin B2 (Riboflavin)

Vitamin B2, also known as riboflavin, is a water-soluble vitamin that is part of the B-complex group. It plays a crucial role in maintaining overall health by participating in various biochemical reactions essential for cellular function and energy production 38. Riboflavin is a precursor to coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are vital for the metabolism of carbohydrates, fats, and proteins .

Vitamin B2 and Colorectal Cancer Risk

Recent meta-analyses have highlighted the potential of vitamin B2 in reducing the risk of colorectal cancer (CRC). A comprehensive dose-response analysis found that higher intake of vitamin B2 is inversely associated with CRC risk. Specifically, an increase in vitamin B2 intake to 5 mg/day was linked to a 10% reduction in CRC risk . Additionally, high blood concentrations of vitamin B2 were also associated with a lower risk of CRC, suggesting the importance of maintaining adequate levels of this vitamin for cancer prevention .

Bioavailability and Effects on Health

A randomized pilot trial comparing natural versus synthetic vitamin B complexes revealed that both forms of riboflavin are bioavailable and effective in increasing serum levels of the vitamin. The study also noted improvements in antioxidant capacity and reductions in oxidative stress and homocysteine levels, which are beneficial for cardiovascular health . This indicates that regular intake of riboflavin, whether from natural or synthetic sources, can support overall health and reduce the risk of chronic diseases.

Vitamin B2 in Depression Prevention

Vitamin B2 has also been studied for its potential role in mental health. A systematic review and meta-analysis found that higher dietary intake of vitamin B2 is associated with a reduced risk of depression, particularly in females. The pooled relative risk for the highest versus the lowest category of dietary vitamin B2 intake was 0.77, indicating a significant inverse relationship . This suggests that adequate riboflavin intake may contribute to mental well-being and help prevent depressive disorders.

Sources and Production of Vitamin B2

Riboflavin is naturally found in various foods, including dairy products, eggs, green leafy vegetables, and meat. It is also produced industrially through microbial fermentation processes involving strains like Ashbya gossypii, Bacillus subtilis, and Candida spp. Advances in genetic and metabolic engineering have optimized these microbial strains to increase riboflavin yield, making supplementation more accessible .

Conclusion

Vitamin B2 (riboflavin) is an essential nutrient with significant health benefits, including reducing the risk of colorectal cancer and depression, and improving antioxidant capacity. Ensuring adequate intake through diet or supplements can support overall health and prevent various chronic conditions. The ongoing research and advancements in riboflavin production further enhance its availability and efficacy as a nutritional supplement.

Sources and full results

Most relevant research papers on this topic

Vitamin B2 intake reduces the risk for colorectal cancer: a dose–response analysis

Vitamin B2 intake is inversely associated with colorectal cancer risk, with a 10% reduction in risk when vitamin B2 intake reaches 5 mg/day.

Meta-AnalysisRigorous Journal

2019·

19citations

·S. Ben et al.

Chemistry of Vitamin B2.

A cold aqueous extract of liver extract (Eli Lilly, No. 343) is very rich in vitamin B2, effectively producing good growth in young rats on a B2 deficient diet at a daily dose of 40-60 mgm.

1931·

2citations

·B. C. Guha

Vitamin B2 (Riboflavin)

Riboflavin or vitamin B2 is a member of the group of vitamins referred to as vitamin B complex, which makes it a water-soluble vitamin. As a drug, healthcare providers often prescribe it in a combined formulation consisting of other B complex vitamins as a prophylactic supplement to prevent the development of deficiency.

2019·

0citations

·B. Peechakara et al.

Production of Vitamin B2 (Riboflavin) by Microorganisms: An Overview

Optimizing riboflavin production in microorganisms through genetic and metabolic engineering can significantly increase their use in nutritional supplements.

Highly Cited

2020·

113citations

·L. Averianova et al.

A Randomized Pilot Trial to Evaluate the Bioavailability of Natural versus Synthetic Vitamin B Complexes in Healthy Humans and Their Effects on Homocysteine, Oxidative Stress, and Antioxidant Levels

Natural and synthetic vitamin B complexes have comparable bioavailability and both show similar effects on antioxidants, homocysteine levels, and oxidative stress.

RCTRigorous Journal

2019·

33citations

·Meinrad Lindschinger et al.

Genome-wide association mapping of vitamins B1 and B2 in common wheat

This study identified 17 loci for vitamin B1 and 7 for vitamin B2 contents in wheat, which could be used to improve vitamin B1 and B2 content for better grain yield and quality.

2017·

21citations

·Jieyun Li et al.

Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis.

Intake of dietary vitamins B1, B2, B6, and B12 may be inversely associated with depression risk, with significant inverse associations observed in females but not in males.

Meta-Analysis

2021·

43citations

·Yanjun Wu et al.

Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5

Essential vitamins B1, B2, B3, and B5 are essential for human health and can be found in various food sources, with the exception of vitamin B3, which can be synthesized from amino acid tryptophan.

Very Rigorous JournalHighly Cited

2022·

109citations

·Marcel Hrubša et al.

Vitamin B biosynthesis in plants.

Vitamin B biosynthesis in plants is complex and essential for diverse metabolic processes, with seven essential vitamins required for human nutrition.

Highly Cited

2007·

162citations

·S. Roje

Determination and assessment of the bioaccessibility of vitamins B1, B2, and B3 in commercially available cereal-based baby foods

The bioaccessibility of vitamins B1, B2, and B3 in cereal-based baby foods may be low in vivo, influenced by stability, temperature, pH of the gastrointestinal tract, dietary fiber content, and bonds with polysaccharides and polypeptides.

2019·

27citations

·Sağre Nur Akça et al.

Try another search

research on anxiety

social determinants of health definition

signs depression is getting worse

rare anxiety symptoms

how long does lithium take to work

cognitive behavioral therapy for social phobia