Vitamin d and zinc together
Pro Research Analysisby 
Searched over 200M research papers
The Combined Effects of Vitamin D and Zinc Supplementation
Introduction to Vitamin D and Zinc Co-Supplementation
Vitamin D and zinc are essential nutrients that play crucial roles in various bodily functions, including immune response, hormonal balance, and metabolic processes. Recent studies have explored the combined effects of these nutrients, particularly in the context of specific health conditions such as polycystic ovary syndrome (PCOS), gestational diabetes mellitus (GDM), and mental health.
Impact on Hormonal Profiles and Inflammation in PCOS
Research indicates that co-supplementation of magnesium, zinc, calcium, and vitamin D can significantly improve hormonal profiles and reduce inflammation in women with PCOS. A study involving 60 women with PCOS showed that this combination led to notable reductions in hirsutism, serum high-sensitivity C-reactive protein (hs-CRP), and plasma malondialdehyde, a marker of oxidative stress. Additionally, there was an increase in plasma total antioxidant capacity, suggesting enhanced oxidative stress management1 5.
Benefits for Gestational Diabetes Mellitus
In women with GDM, magnesium-zinc-calcium-vitamin D co-supplementation has been shown to reduce biomarkers of inflammation and oxidative stress. A randomized trial demonstrated significant decreases in serum hs-CRP and plasma malondialdehyde levels, along with an increase in total antioxidant capacity. These changes were associated with improved pregnancy outcomes, including a trend towards lower newborn weight and reduced rates of macrosomia2 7.
Mental Health and Mood Improvement
The combination of zinc and vitamin D has also been studied for its effects on mood and mental health. In a trial involving obese or overweight patients with mild to moderate depressive symptoms, co-supplementation of zinc and vitamin D significantly reduced depression scores as measured by the Beck Depression Inventory II (BDI-II). However, the supplementation did not significantly affect serum cortisol or brain-derived neurotrophic factor (BDNF) levels4.
Glycemic Control and Cardiometabolic Risk
For women with PCOS, co-supplementation of magnesium, zinc, calcium, and vitamin D has been found to improve glycemic control and reduce markers of cardiometabolic risk. This includes significant reductions in serum insulin levels, insulin resistance, and serum triglycerides, as well as improvements in insulin sensitivity and cholesterol profiles5. Similar benefits were observed in women with GDM, where the supplementation led to better fasting plasma glucose levels and reduced insulin resistance7.
Immune Function and COVID-19
The role of zinc and vitamin D in immune function has gained attention, especially in the context of COVID-19. Studies suggest that adequate levels of these nutrients are crucial for maintaining a robust immune response. Low serum levels of zinc and vitamin D have been associated with increased severity of COVID-19, highlighting the potential benefits of supplementation in improving outcomes for infected individuals8 9.
Conclusion
The combined supplementation of vitamin D and zinc, often with other nutrients like magnesium and calcium, has shown promising results in improving various health outcomes. These include better hormonal balance and reduced inflammation in PCOS, improved glycemic control and pregnancy outcomes in GDM, enhanced mood in depressive symptoms, and potentially better immune responses in viral infections like COVID-19. These findings underscore the importance of considering nutrient co-supplementation as a strategy for managing specific health conditions and improving overall well-being.
Sources and full results
Most relevant research papers on this topic
Magnesium-Zinc-Calcium-Vitamin D Co-supplementation Improves Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial
Magnesium-zinc-calcium-vitamin D co-supplementation for 12 weeks improves hormonal profiles, biomarkers of inflammation, and oxidative stress in women with polycystic ovary syndrome.
RCTThe effects of magnesium-zinc-calcium-vitamin D co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes
Magnesium-zinc-calcium-vitamin D co-supplementation for 6 weeks may reduce inflammation and oxidative stress in women with gestational diabetes, potentially improving pregnancy outcomes.
RCT
Rigorous Journal
Highly CitedZinc, ω-3 polyunsaturated fatty acids and vitamin D: An essential combination for prevention and treatment of cancers.
Zinc, -3 PUFAs, and vitamin D have similar anti-cancer properties and can be combined for beneficial treatment or supplementation, potentially requiring sufficient sufficiency during chemotherapy.
Literature ReviewEffects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial.
Zinc and vitamin D supplements, or their combination, significantly reduced depressive symptoms in obese or overweight patients with BDI-II 10.
RCTA Trial on The Effects of Magnesium-Zinc-Calcium-Vitamin D Co-Supplementation on Glycemic Control and Markers of Cardio-Metabolic Risk in Women with Polycystic Ovary Syndrome.
Magnesium-zinc-calcium-vitamin D co-supplementation for 12 weeks in women with PCOS improved insulin metabolism and markers of cardio-metabolic risk compared to placebo.
RCTEffect of Calcium and Vitamin D on Zinc Balance in Rats
Vitamin D fortification in a diet low in calcium leads to increased urinary loss of zinc and calcium, contradicting previous data on zinc deficiency risk when enriched with calcium.
Very Rigorous JournalMagnesium-zinc-calcium-vitamin D co-supplementation improves glycemic control and markers of cardiometabolic risk in gestational diabetes: a randomized, double-blind, placebo-controlled trial.
Magnesium-zinc-calcium-vitamin D co-supplementation improves glycemic control and reduces cardiometabolic risk markers in gestational diabetes patients.
RCTThe relationship between COVID-19, Zinc and Vitamin D: A Systematic Review
Low zinc levels and COVID-19 are associated with increased hospitalization risk, and vitamin D deficiency may contribute to severe COVID-19 in adults.
Systematic ReviewEarly Nutritional Interventions with Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance Against Progressive COVID-19
Early micronutrient interventions with zinc, selenium, and vitamin D may help reduce inflammation and protect against COVID-19 progression.
Systematic ReviewVery Rigorous JournalHighly CitedSynergistic effect of zinc and vitamin A on the biochemical indexes of vitamin A nutrition in children.
Combined zinc and vitamin A supplementation improves vitamin A nutriture in vitamin A-deficient children, with a lower proportion of children remaining deficient compared to the placebo group.
RCTHighly Cited