Is Vitamin D (D2: Ergocalciferol, And D3: Cholecalciferol) Safe?

Research Analysis by Consensus

Consensus Meter

Yes0%

Possibly0%

No0%

Introduction

Vitamin D, including its forms ergocalciferol (D2) and cholecalciferol (D3), is essential for various physiological functions, including bone health and immune function. The safety and efficacy of these forms of Vitamin D are critical for their therapeutic use.

Key Insights

Efficacy in Increasing Serum 25-Hydroxyvitamin D Levels:
- Both ergocalciferol (D2) and cholecalciferol (D3) are effective in increasing serum 25-hydroxyvitamin D levels in healthy individuals with minimal UV-B exposure. The increases are dose-dependent and similar in magnitude for both forms.
Functional Recovery and Myelination:
- Cholecalciferol (D3) is more effective than ergocalciferol (D2) in promoting nerve regeneration and functional recovery in a rat model of nerve injury. High doses of cholecalciferol significantly improve locomotor and electrophysiological recovery, increase axon diameter, and enhance myelination.

Conclusion

Both ergocalciferol (D2) and cholecalciferol (D3) are safe and effective in increasing serum 25-hydroxyvitamin D levels. However, cholecalciferol (D3) appears to be more effective in promoting nerve regeneration and functional recovery in animal models. Further research, particularly in human clinical trials, is needed to confirm these findings and determine the optimal dosages for therapeutic use.

Is Vitamin D (D2: Ergocalciferol, and D3: Cholecalciferol) safe?

Research Analysis by Consensus

Consensus Meter

Introduction

Key Insights

Conclusion

Sources and full results

Fortified malted milk drinks containing low-dose ergocalciferol and cholecalciferol do not differ in their capacity to raise serum 25-hydroxyvitamin D concentrations in healthy men and women not exposed to UV-B.

Cholecalciferol (Vitamin D3) Improves Myelination and Recovery after Nerve Injury

Relative biopotency of dietary ergocalciferol and cholecalciferol and the role of and requirement for vitamin D in rainbow trout (Salmo gairdneri).

Vitamin D2 vs. Vitamin D3 Supplementation — Does It Matter?

Ergocalciferol versus Cholecalciferol for Nutritional Vitamin D Replacement in CKD

Treatment and prevention of vitamin D insufficiency in cystic fibrosis patients: comparative efficacy of ergocalciferol, cholecalciferol, and UV light.

Vitamin D supplementation: cholecalciferol, calcifediol, and calcitriol

Short and long-term variations in serum calciotropic hormones after a single very large dose of ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3) in the elderly.

The case against ergocalciferol (vitamin D2) as a vitamin supplement.

Relative Efficacy of Vitamin D2 and Vitamin D3 in Improving Vitamin D Status: Systematic Review and Meta-Analysis

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