What are the first signs of kidney disease
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Summary
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These studies suggest that early signs of kidney disease include high blood pressure, diabetes, and the presence of novel biomarkers like asymmetric dimethylarginine and SDMA.
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Early Signs of Kidney Disease
Introduction to Kidney Disease
Kidney disease, including chronic kidney disease (CKD) and diabetic kidney disease (DKD), is a significant health concern worldwide. Early detection is crucial for preventing progression to end-stage renal disease (ESRD). Understanding the first signs of kidney disease can help in timely diagnosis and management.
Microalbuminuria: The First Clinical Sign
Microalbuminuria in Diabetic Kidney Disease
One of the earliest clinical signs of diabetic kidney disease (DKD) is microalbuminuria, which is characterized by moderately increased urine albumin excretion (30-300 mg/24 h or 30-300 mg/g creatinine) . This condition, also known as albuminuria grade A2, indicates that the kidneys are starting to leak small amounts of albumin into the urine, which is not normally present in significant quantities.
Importance of Microalbuminuria Screening
Regular screening for microalbuminuria is essential, especially for patients with diabetes, as it can help identify those at risk of developing more severe kidney damage. Without intervention, microalbuminuria can progress to macroalbuminuria (albuminuria grade A3) and eventually lead to a decline in glomerular filtration rate (GFR) and end-stage renal failure .
Decline in Glomerular Filtration Rate (GFR)
GFR as an Indicator of Kidney Function
A significant reduction in GFR is another early sign of kidney disease. GFR measures how well the kidneys are filtering blood, and a decrease in GFR indicates impaired kidney function . In CKD, a GFR of less than 60 mL/min per 1.73 m² for at least three months is a key diagnostic criterion.
Monitoring GFR
Monitoring GFR is crucial for early detection and management of CKD. Regular blood tests to measure serum creatinine levels, which are used to estimate GFR, can help track kidney function over time .
Peripheral Edema: A Late Symptom
Edema in Advanced Kidney Disease
While microalbuminuria and reduced GFR are early indicators, peripheral edema (swelling in the legs, ankles, and feet) is usually a symptom that appears at a more advanced stage of kidney disease. This occurs due to the kidneys' inability to remove excess fluid from the body.
Non-Specific Symptoms
General Symptoms of CKD
In the early stages, CKD often presents with non-specific symptoms such as lethargy, loss of appetite, and nausea. These symptoms are not unique to kidney disease and can be easily overlooked, making regular screening and monitoring even more important .
Conclusion
Early signs of kidney disease, such as microalbuminuria and a decline in GFR, are critical for timely diagnosis and intervention. Regular screening, especially for high-risk individuals like those with diabetes or hypertension, can help detect these early indicators and prevent progression to more severe stages of kidney disease. Peripheral edema and non-specific symptoms like lethargy and loss of appetite may appear later and should prompt further investigation into kidney function.
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