What are the most common side effects of atorvastatin
Pro Research Analysisby 
Searched over 200M research papers
Common Side Effects of Atorvastatin
Atorvastatin, a widely used statin for lowering cholesterol, is generally well-tolerated but can cause several side effects. This article synthesizes findings from multiple studies to highlight the most common adverse effects associated with atorvastatin.
Muscle-Related Side Effects: Myopathy and Rhabdomyolysis
One of the most serious side effects of atorvastatin is myopathy, which can progress to rhabdomyolysis, a severe condition involving muscle breakdown and potential kidney damage 16. Myopathy can manifest as muscle pain, weakness, and in severe cases, respiratory muscle compromise . The risk of myopathy increases with higher doses and prolonged use of atorvastatin.
Hepatic Side Effects: Liver Function Abnormalities
Atorvastatin can also cause liver-related side effects. Studies have shown that atorvastatin can induce hepatic oxidative stress and apoptotic damage, leading to elevated liver enzymes such as ALT and ALP, increased reactive oxygen species (ROS) production, and altered antioxidant status in the liver . These changes can result in liver function abnormalities, which are critical to monitor during treatment.
Metabolic Side Effects: Insulin Resistance and Increased Glycemia
Another significant side effect of atorvastatin is its impact on glucose metabolism. Research indicates that atorvastatin can decrease insulin sensitivity and increase fasting plasma insulin and glycated hemoglobin levels, leading to insulin resistance and higher blood sugar levels in hypercholesterolemic patients . This side effect is particularly concerning for patients at risk of developing diabetes.
Common Mild Side Effects: Headache, Gastrointestinal Issues
In clinical trials, the most frequently reported mild side effect of atorvastatin was headache. Other common but less severe side effects included gastrointestinal issues such as diarrhea, flatulence, and nausea . These side effects were generally mild and transient, with atorvastatin being well-tolerated at doses up to 80 mg per day.
Conclusion
While atorvastatin is effective in lowering cholesterol and preventing cardiovascular events, it is associated with several side effects. The most serious include myopathy and liver function abnormalities, while more common mild side effects include headache and gastrointestinal issues. Additionally, atorvastatin can impact glucose metabolism, leading to insulin resistance and increased blood sugar levels. Monitoring and managing these side effects are crucial for the safe and effective use of atorvastatin.
Sources and full results
Most relevant research papers on this topic