What does cbg do
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The Multifaceted Role of Cannabigerol (CBG)
Cannabigerol (CBG) is a non-psychoactive cannabinoid derived from the Cannabis sativa plant. Despite being present in low concentrations in the plant, CBG has garnered significant interest due to its diverse pharmacological properties and potential therapeutic applications.
Anti-Inflammatory and Skin Health Benefits
Anti-Inflammatory Properties
CBG has demonstrated potent anti-inflammatory effects. In vitro studies show that CBG can inhibit the release of pro-inflammatory cytokines such as Interleukin-1β, -6, -8, and tumor necrosis factor α, often more effectively than cannabidiol (CBD)1. This makes CBG a promising candidate for treating inflammatory conditions.
Skin Health
CBG has shown significant potential in promoting skin health. It reduces reactive oxygen species levels in human dermal fibroblasts better than vitamin C and has been found to improve transepidermal water loss and reduce redness in clinical studies1. These properties suggest that CBG could be a valuable ingredient in skincare products.
Pain Management
Chemotherapy-Induced Peripheral Neuropathy
CBG has been studied for its potential to alleviate pain, particularly in the context of chemotherapy-induced peripheral neuropathy. Although marketed as an over-the-counter treatment for various forms of pain, research-based evidence supporting its efficacy as an anti-nociceptive agent is still limited2.
Sodium Channel Inhibition
CBG has been found to block voltage-gated sodium (Nav) currents in central nervous system neurons, which may contribute to its analgesic properties. This effect on Nav1.7 channels, a target for analgesic drug development, suggests that CBG could be useful in reducing neuron excitability and managing pain9.
Anti-Cancer Properties
Colon Carcinogenesis
CBG has shown promise in inhibiting colon cancer progression. It blocks the transient receptor potential M8 (TRPM8) channel, promotes apoptosis, stimulates reactive oxygen species production, and reduces cell growth in colorectal cancer cells. These effects were also observed in vivo, where CBG inhibited the growth of xenograft tumors and chemically induced colon carcinogenesis6. This positions CBG as a potential therapeutic agent in colorectal cancer prevention and treatment.
Pharmacological Mechanisms
Receptor Binding and Signaling
CBG interacts with various receptors, including cannabinoid CB1 and CB2 receptors, and modulates endocannabinoid signaling. It acts as a partial agonist at these receptors and influences signaling pathways such as cAMP, pERK, and β-arrestin recruitment4 7. Additionally, CBG affects transient receptor potential (TRP) channels and 5-HT1A receptors, contributing to its broad pharmacological profile7.
Conclusion
Cannabigerol (CBG) is a versatile cannabinoid with a wide range of potential therapeutic applications. Its anti-inflammatory, skin health-promoting, pain-relieving, and anti-cancer properties make it a promising candidate for further research and development. As studies continue to uncover the mechanisms and efficacy of CBG, it may become a valuable component in various medical and cosmetic treatments.
Sources and full results
Most relevant research papers on this topic
In Vitro and Clinical Evaluation of Cannabigerol (CBG) Produced via Yeast Biosynthesis: A Cannabinoid with a Broad Range of Anti-Inflammatory and Skin Health-Boosting Properties
CBG, a minor non-psychoactive cannabinoid produced via yeast fermentation, shows potential as a safe and effective topical ingredient for improving skin health, with potential advantages over CBD in certain areas.
Cannabigerol (CBG) attenuates mechanical hypersensitivity elicited by chemotherapy‐induced peripheral neuropathy
Cannabigerol (CBG) effectively reduces mechanical hypersensitivity in chemotherapy-induced peripheral neuropathy, but its efficacy as an anti-nociceptive agent remains inconclusive.
Non-RCTCBG: a binding story
CBG serves as a pre-receptor control mechanism for cortisol delivery, with elastase-induced cleavage potentially perpetuating inflammation in chronic inflammation.
Cannabigerol Action at Cannabinoid CB1 and CB2 Receptors and at CB1–CB2 Heteroreceptor Complexes
Cannabigerol (CBG) is a partial agonist of CB2 receptor and effectively regulates endocannabinoid signaling, with potential therapeutic applications in treating various diseases.
In Vitro Study
Highly CitedCortisol and CBG - Getting cortisol to the right place at the right time.
CBG acts as both a carrier and releasing agent of cortisol, offering potential for targeted drug delivery and therapeutic interventions.
Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid.
Cannabigerol, a non-psychotropic cannabinoid, inhibits colon cancer progression and selectively inhibits the growth of colorectal cancer cells, suggesting potential for colon cancer prevention and cure.
In Vitro StudyHighly CitedPharmacological Aspects and Biological Effects of Cannabigerol and Its Synthetic Derivatives
Cannabigerol (CBG) shows potential as a therapeutic agent for various disorders due to its antioxidant, anti-inflammatory, and neuroprotective properties.
Rigorous JournalInteraction of human CBG with cell membranes
Both normal CBG and pregnancy-associated pCBG play a role in guided transport of steroid hormones to target cells and transmembrane transfer of hormones and hormonal signals.
In Vitro StudyHighly CitedInhibition of sodium conductance by cannabigerol contributes to a reduction of dorsal root ganglion neuron excitability
Cannabigerol reduces dorsal root ganglion neuron excitability by inhibiting sodium conductance, potentially contributing to its analgesic properties.
Very Rigorous JournalCorticosteroid-Binding Globulin: A Review of Basic and Clinical Advances
CBG plays a multifaceted role in maintaining homeostasis, with implications in acute and chronic inflammation, metabolism, and neurocognitive function.
Literature ReviewHighly Cited