What is the drug hydroxyzine hcl used for

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Uses of Hydroxyzine HCL

Treatment of Allergic Skin Conditions

Antihistamine Properties

Hydroxyzine HCL (HHCL) is primarily used as an antihistamine for treating allergic skin conditions such as urticaria and atopic dermatitis. It works by blocking histamine receptors, which helps reduce symptoms like itching and swelling 12.

Topical Delivery Systems

Recent studies have explored various delivery systems to enhance the efficacy and reduce the side effects of HHCL. For instance, a study formulated HHCL solid lipid nanoparticles (SLNs) for transdermal delivery. This method aimed to improve drug permeation through the skin and avoid the extreme bitterness associated with oral administration. The transdermal gel loaded with SLNs demonstrated potent antipruritic efficacy in atopic dermatitis models .

Side Effects and Controlled Release

Common Side Effects

Oral formulations of HHCL are associated with side effects such as dizziness, blurred vision, and anticholinergic responses. These side effects can be significant and limit the drug's usability for some patients .

Controlled Release Formulations

To mitigate these side effects, controlled release formulations have been developed. One such approach involves the use of the Microsponge Delivery System, which consists of porous polymeric microspheres loaded with HHCL. This system allows for a controlled release of the drug into the skin, thereby reducing percutaneous absorption and minimizing side effects. The microsponges showed high encapsulation efficiency and significant porosity, making them effective for topical delivery .

Conclusion

Hydroxyzine HCL is a versatile antihistamine used primarily for treating allergic skin conditions. Innovations in drug delivery systems, such as solid lipid nanoparticles and microsponges, have shown promise in enhancing the drug's efficacy and reducing its side effects. These advancements could potentially offer more effective and patient-friendly treatment options for conditions like urticaria and atopic dermatitis.

Sources and full results

Most relevant research papers on this topic

Formulation and assessment of hydroxyzine HCL solid lipid nanoparticles by dual emulsification technique for transdermal delivery.

Hydroxyzine HCL solid lipid nanoparticles transdermal gel shows potential for alternative delivery of hydroxyzine HCL and may offer a better alternative to traditional oral use for treating allergic skin conditions.

Non-RCTAnimal StudyRigorous Journal

2021·

18citations

·Dalia F El-Telbany et al.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·

DOI

In Vitro and In Vivo Evaluation of Hydroxyzine Hydrochloride Microsponges for Topical Delivery

The developed microsponges effectively control the release of hydroxyzine hydrochloride into the skin, reducing side effects and percutaneous absorption while maintaining therapeutic efficacy.

In Vitro Study

2011·

62citations

·Christianne Mounir Zaki Rizkalla et al.

AAPS PharmSciTech·

DOI

Plasma and urine pharmacokinetics of hydroxyzine and cetirizine following repeated oral administrations to exercised horses.

This study developed a pharmacokinetic model to predict detection times of hydroxyzine and cetirizine in thoroughbred horses, providing screening limits for a detection time of 4 days in either plasma or urine.

Non-RCTAnimal Study

2021·

1citation

·S. Paine et al.

Journal of veterinary pharmacology and therapeutics·

DOI

A preliminary randomised double-blind placebo-controlled clinical trial of hydroxyzine for treating sleep bruxism in children.

Hydroxyzine is effective and well-tolerated for treating sleep bruxism in children, with no serious adverse effects reported.

RCT

2013·

25citations

·A. Ghanizadeh et al.

Journal of oral rehabilitation·

DOI

A fatal case involving hydroxyzine.

Hydroxyzine, a prescription drug for anxiety and sedation, can cause fatalities when ingested suicidally, with no other fatal cases reported in the literature.

Case Report

1982·

20citations

·G. R. Johnson

Journal of analytical toxicology·

DOI

Real-World, Non-Interventional, Observational Study of Hydroxyzine Hydrochloride in Chronic Pruritus: a Prospective, Non-Comparative Study

Hydroxyzine significantly improves symptoms and quality of life in patients with chronic pruritus due to dermatological causes, and is well tolerated in real-world settings.

Non-RCTLarge Human Trial

2019·

6citations

·Jayakar Thomas et al.

Dermatology and Therapy·

DOI

Stress. Psychophysiological and cognitive indices in an acute double-blind study with hydroxyzine in psychiatric patients.

Hydroxychloride effectively reduces information processing capability and central nervous system activation in psychiatric patients experiencing physical and cognitive stress.

1967·

15citations

·V. Pishkin et al.

Archives of general psychiatry·

DOI

Formulation and Evaluation of Taste Masked Fast Dissolving/ Disintegrating Tablets of Hydroxyzine Hydrochloride

Taste masking techniques using ion exchange resin and Indion-234 successfully create palatable mouth dissolving tablets of Hydroxyzine hydrochloride, improving patient compliance.

In Vitro Study

2014·

1citation

·P. Pawar et al.

Asian Journal of Pharmacy and Technology

Safety of hydroxyzine in the sedation of pediatric dental patients

Hydroxyzine is a safe oral sedative for pediatric dentistry, with potential side effects of drowsiness and dry mouth, but no serious adverse events when used properly and administered correctly.

Systematic ReviewVery Rigorous Journal

2022·

4citations

·Tae-Gyeong Kim et al.

Journal of Dental Anesthesia and Pain Medicine·

DOI

Hydroxyzine distribution in postmortem cases and potential for redistribution.

Hydroxyzine is prone to moderate postmortem redistribution, with concentrations in peripheral blood and liver potentially being therapeutic at therapeutic levels.

Observational Study

2013·

22citations

·Iain M McIntyre et al.

Forensic science international·

DOI

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