What is the relationship between the immune system and chronic diseases like cancer and autoimmune conditions?

Introduction

The relationship between the immune system and chronic diseases such as cancer and autoimmune conditions is complex and multifaceted. Recent research has highlighted significant interactions between chronic inflammation, autoimmunity, and cancer development, suggesting a bidirectional and dynamic link.

Key Insights

Chronic Inflammation and Cancer Development
- Chronic inflammation, often driven by autoimmune responses, increases cellular proliferation and the risk of malignant transformation .
- Autoimmune diseases are associated with an increased risk of cancer due to the persistent inflammatory environment they create .
Bidirectional Relationship
- Autoimmune diseases can increase the risk of cancer, and conversely, cancer can trigger autoimmune-like conditions .
- Antitumor immune responses may become cross-reactive with self-tissues, leading to autoimmunity .
Immune Dysregulation
- Both autoimmunity and cancer involve immune dysregulation, where the immune system fails to properly regulate itself, leading to either uncontrolled cell growth (cancer) or attack on self-tissues (autoimmunity) .
- The immune system's role in both conditions suggests that therapies targeting immune regulation need careful consideration to avoid exacerbating either condition .
Role of Microbiota
- The microbiota plays a crucial role in modulating the immune response, and dysbiosis can lead to both autoimmune diseases and cancer by altering immune homeostasis.
Genetic and Environmental Factors
- Genetic predispositions and environmental factors contribute to the susceptibility to both autoimmune diseases and cancer, highlighting the need for personalized approaches in treatment and prevention .

Conclusion

The relationship between the immune system and chronic diseases like cancer and autoimmune conditions is characterized by a complex interplay of chronic inflammation, immune dysregulation, and genetic and environmental factors. Chronic inflammation from autoimmune diseases can promote cancer development, while cancer can trigger autoimmune responses. Understanding these interactions is crucial for developing effective therapies and preventive strategies.

What is the relationship between the immune system and chronic diseases like cancer and autoimmune conditions?

Summary

Introduction

Key Insights

Conclusion

Sources and full results

Multiple associations between a broad spectrum of autoimmune diseases, chronic inflammatory diseases and cancer.

Chronic inflammation and autoimmune diseases are associated with the development of malignancy, highlighting the need for surveillance of patients on immunomodulatory therapies for potential secondary diseases.

Autoimmunity and cancer.

Autoimmunity and cancer have a dynamic and bidirectional link, with chronic inflammation from rheumatic diseases or their therapies potentially contributing to cancer onset and promotion.

Autoimmunity as an Etiological Factor of Cancer: The Transformative Potential of Chronic Type 2 Inflammation

Autoimmunity may be a causal factor for cancer development, with chronic type 2 inflammation potentially playing a transformative role in epigenetic reprogramming and malignant transformation.

Beneficial autoimmunity and maladaptive inflammation shape epidemiological links between cancer and immune-inflammatory diseases

Autoimmune responses against self-antigens can drive chronic inflammation and reduce cancer incidence and progression, potentially explaining positive associations between immune-inflammatory diseases and cancer.

The Link "Cancer and autoimmune diseases" in the light of microbiota: evidence of a potential culprit.

Microbiota may play a potential link between autoimmune diseases and cancer, altering immune tonus and favoring the onset of neoplastic and autoimmune diseases.

Cancer and autoimmune diseases.

Recent data suggests a small to no increase in cancer risk from autoimmune disorders and immunosuppressive therapy, and new associations with malignancies have been discovered.

Autoimmuno-Anti-Tumor Immunity – Understanding the Immune Responses against “self” and “Altered-Self”

Chronic inflammation contributes to tumor development, and targeting negative immune regulation may enhance host immunity against cancer.

Can Cancer Trigger Autoimmunity?

Cancer may express new proteins (neoantigens) that can trigger an autoimmune disease, potentially affecting tissues and organs.

Autoimmunity and Cancer, the Paradox Comorbidities Challenging Therapy in the Context of Preexisting Autoimmunity.

Autoimmune diseases and cancer create a paradoxical challenge for treating both diseases, as current cancer therapies aim to activate the immune system to create autoimmune-like conditions and eliminate tumors.

Autoantibodies, Autoimmunity and Cancer

Autoimmunity and cancer share a close relationship, with immune dysregulation playing a pathogenic role in both conditions.

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