What are the signs of early kidney disease?

Introduction

Early kidney disease, also known as early-stage chronic kidney disease (CKD), is a condition where the kidneys begin to lose their function gradually. Identifying early signs of CKD is crucial for timely intervention and management to prevent progression to more severe stages.

Key Insights

Cardiovascular Changes:
- Early CKD is associated with increased diffuse myocardial fibrosis and left ventricular (LV) hypertrophy, which are linked to impaired systolic function and increased cardiovascular risk .
Pregnancy Complications:
- Women with early-stage CKD face higher risks during pregnancy, including increased rates of preterm delivery, cesarean sections, and the need for neonatal intensive care. Proteinuria and hypertension are significant predictors of these adverse outcomes.
Developmental Factors:
- Renal disease can originate early in life due to factors such as low birth weight, congenital abnormalities, and adverse postnatal events. These early-life conditions can predispose individuals to hypertension and renal insufficiency later in life.

Conclusion

Early kidney disease is marked by cardiovascular changes such as myocardial fibrosis and LV hypertrophy, which increase cardiovascular risk. Pregnant women with early CKD are at higher risk for complications, and early-life factors can predispose individuals to renal disease. Early detection and management are essential to mitigate these risks and prevent disease progression.

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What are the signs of early kidney disease?

Summary

Introduction

Key Insights

Conclusion

Sources and full results

Diffuse interstitial fibrosis and myocardial dysfunction in early chronic kidney disease.

Diffuse myocardial fibrosis is increased in early chronic kidney disease and is associated with abnormal global longitudinal strain, indicating an early uremic cardiomyopathy and adverse cardiovascular prognosis.

Early stage chronic kidney disease: a paradigm for diffuse fibrosis and clinical progression

Early stage chronic kidney disease is associated with increased diffuse fibrosis and reduced aortic distensibility, potentially contributing to increased cardiovascular risk.

Pregnancy and chronic kidney disease: a challenge in all CKD stages.

Chronic kidney disease (CKD) is a challenge for pregnancy from early stages, with higher risks of preterm delivery, cesarean section, and neonatal intensive care.

Early origin of adult renal disease

Early childhood risk factors, such as low birth weight, congenital abnormalities, and poor nutrition, can contribute to adult kidney disease.

Symptoms in the month before death for stage 5 chronic kidney disease patients managed without dialysis.

Stage 5 chronic kidney disease patients without dialysis experience significant physical and psychological symptoms in the last month of life, similar or greater than those in advanced cancer patients.

Cutaneous manifestations of end-stage renal disease.

End-stage renal disease can cause various skin and nail abnormalities, including pruritus, perforating disorders, calcifying disorders, and bullous dermatoses.

Early recognition and prevention of chronic kidney disease

Early diagnosis and prevention of chronic kidney disease can reduce the risks of cardiovascular events, kidney failure, and death.

Novel Biomarkers in the Diagnosis of Chronic Kidney Disease and the Prediction of Its Outcome

Novel biomarkers, such as asymmetric dimethylarginine and SDMA, show promise in diagnosing chronic kidney disease and predicting its outcome, but their efficacy, sensitivity, and specificity require confirmation and reduced analysis costs.

Development of a risk score for earlier diagnosis of chronic kidney disease in children

The developed clinical score may serve as a warning sign for early diagnosis of chronic kidney disease in children, potentially reducing morbidity and mortality.

Early referral strategies for management of people with markers of renal disease: a systematic review of the evidence of clinical effectiveness, cost-effectiveness and economic analysis.

Early referral strategies for people with chronic kidney disease can reduce mortality and progression, but more research is needed.

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