Why is protein important

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The Importance of Protein: A Comprehensive Overview

Essential Proteins and Cellular Function

Keywords: essential proteins, cellular function, protein-protein interactions

Proteins are fundamental to the survival and proper functioning of cells. Essential proteins, in particular, are indispensable for cellular life. When these proteins are destroyed, cells either die or stop reproducing, highlighting their critical role in maintaining cellular integrity 149. Essential proteins are often more evolutionarily conserved and tend to interact frequently with other essential proteins, forming complex networks that are vital for cellular processes 49. Computational methods have become increasingly popular for identifying these proteins due to the inefficiencies of traditional biological experimental methods 14.

Protein's Role in the Food Industry

Keywords: food industry, functional properties, nutritional value

In the food industry, proteins are crucial due to their diverse functional properties and high nutritional value. They play a significant role in the structure and texture of various food products. Proteins from different sources, such as plant, animal, and synthetic origins, are used to enhance the nutritional profile and functional characteristics of food items 25. The modification and application of these proteins in food manufacturing are essential for developing new food products and improving existing ones 25.

Structural and Functional Importance of Proteins in the Body

Keywords: body structure, muscle repair, hormone regulation

Proteins are critical to the structure and function of the human body. They help maintain fluid and electrolyte balance, aid in energy production, and act as buffers to maintain the body's pH levels. Proteins are also involved in the building and repair of muscles, the transport of micronutrients, and the regulation of hormones related to metabolism . They are composed of amino acids, which are the building blocks necessary for various physiological processes 36.

Protein-Protein Interactions and Cellular Environment

Keywords: protein-protein interactions, cellular environment, macromolecular crowding

Protein-protein interactions are essential for proper cellular function. These interactions are influenced by the cellular environment, including factors like macromolecular crowding and chemical interactions. Studies have shown that the stability of protein complexes can vary significantly between different cellular environments, such as prokaryotic and eukaryotic cells 810. Understanding these interactions is crucial for comprehending how proteins function within the crowded cellular milieu and how they contribute to cellular processes 810.

Multifunctional Proteins and Disease

Keywords: multifunctional proteins, moonlighting proteins, disease

Some proteins, known as moonlighting proteins, exhibit more than one physiologically relevant function within a single polypeptide chain. These multifunctional proteins play central roles in various diseases and are involved in multiple biochemical processes. For instance, members of the heat shock protein families (HSP10, HSP70, HSP90, HSP100, and HSP110) have been identified as moonlighting proteins, performing critical functions under different physiological conditions . Understanding the diverse roles of these proteins can aid in the development of novel therapeutic strategies .

Conclusion

Proteins are indispensable for life, playing critical roles in cellular function, food industry applications, and overall body structure and function. Essential proteins are vital for cell survival, while multifunctional proteins contribute to complex physiological processes and disease mechanisms. The study of protein-protein interactions and the impact of the cellular environment on these interactions further underscores the importance of proteins in maintaining life. Understanding these diverse roles highlights the multifaceted significance of proteins in both health and disease.

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Most relevant research papers on this topic

A novel extended pareto optimality consensus model for predicting essential proteins.

The E_POC model, combining orthologous, edge-clustering coefficient, and gene expression information, effectively predicts essential proteins in S. cerevisiae and E. coli cells.

2019·

10citations

·Gaoshi Liet al.

Journal of theoretical biology

The Importance of Protein in Food Industry

Proteins play a crucial role in the food industry due to their diverse functional properties and higher nutritive value, with applications in various food structures and their modification methods.

2009·

0citations

·Dong Sainan

Meat Research

Principles of Protein

Proteins are essential for maintaining body structure and function, aiding in energy production, and maintaining fluid and electrolyte balance.

Highly Cited

1980·

85citations

·J. Séquaris

Bioelectrochemistry and Bioenergetics

Essential protein discovery based on a combination of modularity and conservatism.

The proposed method, combining modularity and conservatism, effectively identifies essential proteins, outperforming other methods in terms of number of top-ranked candidates.

2016·

32citations

·Bi-hai Zhaoet al.

Methods

Food Proteins: Technological, Nutritional, and Sustainability Attributes of Traditional and Emerging Proteins.

Cultured meat and insect-derived proteins show potential for nutritional, technological, and environmental sustainability in food production, with potential for future food applications.

Highly Cited

2019·

199citations

·S. Loveday

Annual review of food science and technology

Biochemical Importance of Individual Amino-Acids

Essential amino-acids are those that are essential for maintaining normal growth and maintaining body weight in animals, and their absence can lead to death.

1944·

2citations

·T. Dixon

Nature

Protein moonlighting: what is it, and why is it important?

Moonlighting proteins, which exhibit multiple functions within one polypeptide chain, play a central role in many diseases and could be targeted by novel treatments.

Highly Cited

2018·

271citations

·C. Jeffery

Philosophical Transactions of the Royal Society B: Biological Sciences

The intracellular environment affects protein–protein interactions

Chemical interactions play a more important role than hard-core repulsions in stabilizing protein-protein interactions under physiological conditions.

In Vitro Study

2021·

61citations

·Shannon L. Speeret al.

Proceedings of the National Academy of Sciences

A Topology Potential-Based Method for Identifying Essential Proteins from PPI Networks

Topology potential-based methods TP and TP-NC outperform traditional centrality measures in identifying essential proteins in protein-protein interaction networks.

Highly Cited

2015·

91citations

·Min Liet al.

IEEE/ACM Transactions on Computational Biology and Bioinformatics

Atomic-level characterization of protein–protein association

Atomic-level simulations reveal that protein-protein complexes form through spontaneous association and dissociation, with native association achieved through dissociation and reassociation near the native interface.

Highly Cited

2018·

169citations

·Albert C. Panet al.

Proceedings of the National Academy of Sciences of the United States of America

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