Withdrawal symptoms from losartan

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Withdrawal Symptoms from Losartan: An Overview

Introduction to Losartan and Its Use

Losartan is a widely used antihypertensive medication that functions as a selective antagonist of the angiotensin II type 1 (AT1) receptor. It is commonly prescribed to manage high blood pressure and to protect the kidneys from damage due to diabetes. Understanding the potential withdrawal symptoms associated with losartan is crucial for both patients and healthcare providers.

Common Adverse Experiences with Losartan

Clinical trials have shown that losartan is generally well-tolerated. The most frequently reported adverse experiences include headache, upper respiratory infection, dizziness, asthenia (fatigue), and coughing. These symptoms were also commonly reported in patients treated with a placebo, indicating that they may not be directly related to losartan itself 12.

Withdrawal Symptoms and Rebound Hypertension

One of the significant concerns with discontinuing antihypertensive medications is the potential for withdrawal symptoms, such as rebound hypertension. However, clinical trials have demonstrated that losartan does not typically cause withdrawal effects like rebound hypertension. This makes it a safer option for patients who may need to discontinue the medication for various reasons .

Comparison with Other Antihypertensive Agents

When compared to other antihypertensive agents such as ACE inhibitors, beta-blockers, and calcium channel blockers, losartan has shown a favorable safety and tolerability profile. The incidence of drug-related adverse experiences and the rate of withdrawal due to these experiences were lower for losartan than for placebo and other antihypertensive drugs 12.

Conclusion

In summary, losartan is a well-tolerated antihypertensive medication with a low incidence of withdrawal symptoms. Clinical trials have not observed significant withdrawal effects, such as rebound hypertension, making it a reliable choice for long-term management of hypertension. Patients and healthcare providers can be reassured by its excellent safety profile and minimal risk of adverse withdrawal effects.

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Most relevant research papers on this topic

Safety and tolerability of losartan compared with atenolol, felodipine and angiotensin converting enzyme inhibitors

Losartan has demonstrated an excellent tolerability profile in controlled clinical trials compared to other antihypertensive agents, with no significant differences observed for demographic subgroups.

RCTLarge Human Trial

1995·

34citations

·A. Goldberget al.

Journal of Hypertension

Efficacy and safety of losartan.

Losartan is an effective and well-tolerated antihypertensive agent, with a smooth antihypertensive profile and similar effects to other drugs, with dizziness being the most common adverse experience.

RCTLarge Human Trial

1995·

17citations

·A. Goldberget al.

The Canadian journal of cardiology

Safety and tolerability of losartan potassium, an angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension.

Losartan potassium is an effective and well-tolerated treatment for systemic hypertension, with a better tolerability profile than other antihypertensive agents.

Highly Cited

1995·

272citations

·A. Goldberget al.

The American journal of cardiology

Efficacy and tolerability of losartan potassium and atenolol in patients with mild to moderate essential hypertension.

Losartan is as effective as atenolol in reducing blood pressure in patients with mild to moderate essential hypertension, and both drugs are well-tolerated.

RCTHighly Cited

1995·

101citations

·B. Dahlöfet al.

American journal of hypertension

Ethanol Withdrawal Alters the Oxidative State of the Heart Through AT1-Dependent Mechanisms.

Ethanol withdrawal alters the cardiac oxidative state through AT1-dependent mechanisms, with angiotensin II/AT1 receptors playing a role in the initial steps of these cardiac effects.

Non-RCTAnimal Study

2019·

3citations

·Victor O. Assiset al.

Alcohol and alcoholism

Ethanol withdrawal increases blood pressure and vascular oxidative stress: a role for angiotensin type 1 receptors.

Ethanol withdrawal increases blood pressure and vascular oxidative stress through AT1-dependent mechanisms, with angiotensin II playing a key role in these responses.

Non-RCTAnimal Study

2018·

8citations

·Natália A. Gonzagaet al.

Journal of the American Society of Hypertension : JASH

Continuum of renoprotection with losartan at all stages of type 2 diabetic nephropathy: a post hoc analysis of the RENAAL trial results.

Losartan therapy effectively reduces the risk of ESRD and heart failure in individuals with type 2 diabetes and overt nephropathy, and is well-tolerated at all levels of renal function.

Highly Cited

2004·

109citations

·G. Remuzziet al.

Journal of the American Society of Nephrology : JASN

Effects of losartan and captopril on left ventricular volumes in elderly patients with heart failure: results of the ELITE ventricular function substudy.

Both captopril and losartan prevent left ventricular dilation in elderly patients with heart failure, but the relative effects on ventricular remodeling do not provide a survival benefit for losartan over captopril.

RCTHighly Cited

2000·

101citations

·M. Konstamet al.

American heart journal

Main results of the losartan versus amlodipine (LOA) study on drug tolerability and psychological general well‐being

Losartan and amlodipine effectively lower blood pressure, but amlodipine has higher drug-related adverse effects and withdrawal rates.

RCTLarge Human Trial

1997·

57citations

·B. Dahlöfet al.

Journal of Hypertension

An inpatient trial of the safety and efficacy of losartan compared with placebo and enalapril in patients with essential hypertension

Losartan effectively reduces blood pressure in patients with essential hypertension, with a slower onset of action than enalapril, and is well-tolerated and well-tolerated compared to placebo and enalapril.

RCT

1996·

3citations

·R. Byynyet al.

Cardiovascular Drugs and Therapy

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