Antonio E. Elia, S. Lalli, M. Monsurrò
Feb 9, 2015
Citations
11
Influential Citations
177
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Quality indicators
Journal
European Journal of Neurology
Abstract
Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid that is produced in the liver and used for treatment of chronic cholestatic liver diseases. Experimental studies suggest that TUDCA may have cytoprotective and anti‐apoptotic action, with potential neuroprotective activity. A proof of principle approach was adopted to provide preliminary data regarding the efficacy and tolerability of TUDCA in a series of patients with amyotrophic lateral sclerosis (ALS).