I. M. Coupar, Annmarie Hedges, H. Metcalfe
Jul 1, 1969
Citations
0
Influential Citations
16
Citations
Quality indicators
Journal
Journal of Pharmacy and Pharmacology
Abstract
Butalamine, (3-phenyl-5-dibutylaminoethyl-amino1,2,4-oxadiazole) and imolamine, (3-phenyl5-imino-4-diethylaminoethyl-l,2,4-oxadiazole), have been shown to produce in animals coronary vasodilation, local anaesthesia, analgesia and a papaverine like action in duodenal preparations (Sterne & Hirsch, 1964, 1965). We have now investigated the spasmolytic activity of these drugs on isolated, spontaneously-active, human smooth muscle tissue and compared them with aminophylline. The tissue was fresh from operation specimens. Strips were prepared and suspended in an organ bath containing Krebs bicarbonate solution at 37" gassed with 5% carbon dioxide in oxygen. The effects of the drug on the rate of spontaneous activity, the amplitude of contractions and tone were recorded on a smoked kymograph drum. The results are in Table 1. The anti-acetylcholine properties of the compounds were also investigated by measuring the reduction in height of acetylcholine-induced contractions.