N. Viswanadh, R. Velayudham, S. Jambu
Sep 16, 2015
Citations
0
Influential Citations
13
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A simple and efficient synthesis of chiral drugs (R)-mexiletine 1, an anti-arrhythmic drug and (R)-phenoxybenzamine hydrochloride 2, an anti-hypertensive drug has been described via controlled reductive ring opening of chiral aziridine as a key step. The target compounds 1 and 2 were obtained in overall yields of 34% and 10.5%, respectively.