Andreas Helfer, Johnny Castillo Meleán, J. Ermert
Dec 1, 2013
Citations
0
Influential Citations
12
Citations
Journal
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Abstract
4-[¹⁸F]Fluorophenol is a very useful intermediate compound for building-up more complex molecules bearing a 4-[¹⁸F]fluorophenoxy moiety. Bis(4-benzyloxyphenyl)iodonium salts proved very effective as labeling precursors for the radiosynthesis of this compound in no-carrier-added form. Starting from the bromide salt and performing the radiofluorination by conventional heating, 4-[¹⁸F]fluorophenol was obtained in an overall RCY of 43 ± 12% while a yield of 52 ± 3% was achieved more reliably starting from the tosylate salt and employing microwave heating.