M. Hosseini, Henriette Kringelum, A. Murray
Apr 22, 2006
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0
Influential Citations
44
Citations
Journal
Organic letters
Abstract
[reaction: see text] Pyrrolidine-2,4-diones (1) are naturally occurring analogues of amino acids. We herein present a facile synthesis of N-acylated, O-alkylated pyrrolin-2-ones (2) in high yield and excellent enantiopurity. Molecular mechanics calculations suggest that the resulting dipeptide analogues adopt a linear, extended conformation.