Laura Lorenzo-Soler, Pitsiree Praphanwittaya, O. B. Olafsdottir
Jan 26, 2022
Citations
0
Influential Citations
3
Citations
Quality indicators
Journal
Acta Ophthalmologica
Abstract
Tyrosine kinase inhibitors inhibit VEGF receptors. If delivered to the retina, they might inhibit oedema and neovascularization such as in age‐related macular degeneration and diabetic retinopathy. The aim of this study was to formulate cediranib maleate, a potent VEGF inhibitor, as γ‐cyclodextrin nanoparticle eye drops and measure the retinal delivery and overall ocular pharmacokinetics after a single‐dose administration in rabbits.