Pavel V. Khodakovskiy, Pavel K. Mykhailiuk, D. Volochnyuk
Mar 1, 2010
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Influential Citations
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Synthesis
Abstract
A set of electrophilic 2-(trifluoroacetyl)-1,3-azoles demonstrated excellent activity in the C-oxyalkylation of pyrrole, furan, thiophene, 1,3-thiazole, and 1,2-oxazole derivatives. The re- action conditions and the yields of the corresponding trifluorometh- yl-substituted alcohols depend strongly on both the electronic and steric nature of the 1,3-azole unit.