Lai Xiao-ping
2010
Citations
0
Influential Citations
1
Citations
Quality indicators
Journal
Traditional Chinese Drug Research and Clinical Pharmacology
Abstract
Objective To establish the Caco-2 cell model and to explore its application to the research of absorption characteristics of Chinese Medicine.Methods The Caco-2 cell model was evaluated by morphological feature,transepithelial electrical resistance(TEER) and the transport of lucifer yellow.Results The Caco-2 cell model has been established in this experiment.The determined values met the requirements,and the integrality,permeability and the transportation of lucifer yellow in the cell model were good.Conclusion The established Caco-2 cell model can be used to study the absorption mechanism of chemical components of oral Chinese medicine.High-sensitivity analytical instruments can promote the maximum application of Caco-2 cell model in the absorption research of chemical components of Chinese medicine.The absorption research of interaction between two or more chemical components of Chinese Medicine will supply scientific evidence for compatibility of traditional Chinese drugs and application of compound prescriptions of Chinese Medicine.