Bhawana Sethi, R. Mazumder
Oct 1, 2016
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Influential Citations
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Citations
Quality indicators
Journal
Imperial journal of interdisciplinary research
Abstract
: Transdermal drug delivery system has been seen a veritable explosion in the past decades. In the present scenario, very few transdermal patches are available. Matrix-diffusion type transdermal film of Aliskiren Hemifumarate was designed with varying concentration of Methocel (K15 & K100), Ethocel (4 & 10), Gelatin, Chitosan, Eudragit RL & RS grade. Aliskiren is orally active direct renin inhibitor that lowers blood pressure alone or in combination with other antihypertensive agents. The drug has oral bioavailability ~2.6 %. The formulation A, D & E shows better in vitro release & physical parameters like weight variation, Percentage Moisture Absorption, Percentage Moisture loss, Water Vapor Transmission Rate, Thickness & Content Uniformity. In vitro release studies showed zero-order release from all the patches. The permeation was studies were carried out for 24h showing release up to 37.86 % for A, 36.19% for D & 39.58 for E. No erythema or odema was observed on the skin after the application of the patch (A, D & E) for 24h.