A. Dorszewski, B. Müller-Beckmann, L. Kling
Nov 1, 1990
Citations
0
Influential Citations
8
Citations
Quality indicators
Journal
British Journal of Pharmacology
Abstract
1 This study was performed to investigate whether cardiac positive inotropic as well as peripheral vasodilator properties of adibendan contribute to its overall haemodynamic profile in conscious dogs. 2 Haemodynamic measurements were carried out in conscious chronically instrumented dogs after administration of adibendan, sodium nitroprusside or dobutamine. 3 The cardiovascular changes induced by adibendan (0.01 and 0.03 mg kg−1) resembled those of dobutamine (1.0–4.0 μg kg−1 min−1): left ventricular dP/dt60 (LV dP/dt60), stroke volume (SV) and cardiac output (CO) increased to a similar extent, but mean arterial pressure (MAP) and heart rate (HR) remained unchanged. 4 In contrast to dobutamine, higher doses of adibendan (0.1–1.0 mg kg−1) decreased MAP and LVEDP. These effects were of a similar magnitude to those observed following nitroprusside administration (0.5–12.5 μg kg−1 min−1). In contrast to nitroprusside, adibendan still showed additional effects on LV dP/dt60 and CO. 5 From these results, it is concluded that both the peripheral vasodilator and the cardiac positive inotropic action of adibendan contribute to its overall haemodynamic profile.