S. Qing-hong
2008
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Journal
Chinese Journal of Pharmaceutical Analysis
Abstract
Objective:To establish HPLC method for the determination of hydrochloride phenoxybenzamine tablets. Method:Agilent Eclipse XDB-C_(18)column(4.6 mm×250 mm,5 μm),with the mobile phase consisted of metha- nol-water(80:20),the flow rate was 1.0 mL·min~(-1),detection wavelength at 272 nm,the injection volume was 20 μL and external standard method.Results:The linear range of the method was 1.0-200 μg·mL~(-1)(r= 0.9999),the limit of detection was 1.0 ng,the average recovery of artemether was 99.7 %~101.0%,with RSD of 0.68%-2.2%(n=5).Conclusion:The method is simple,sensitive,accurate and can be used for the determina- tion hydrochloride phenoxybenzamine tablets.