P. Deshpande, V. Nanduri, A. Pullockaran
May 22, 2008
Citations
0
Influential Citations
4
Citations
Journal
Journal of Industrial Microbiology & Biotechnology
Abstract
Microbial hydroxylation of o-bromophenylacetic acid provided 2-bromo-5-hydroxyphenylacetic acid. This enabled a route to the key intermediate 4-bromo-2,3-dihydrobenzofuran for synthesizing a melatonin receptor agonist and sodium hydrogen exchange compounds. Pd-mediated coupling reactions of 4-bromo-2,3-dihydrobenzofuran provided easy access to the 4-substituted-2,3-dihydrobenzofurans.