S. Woodward
Mar 1, 1981
Citations
0
Influential Citations
3
Citations
Quality indicators
Journal
Journal of toxicology and environmental health
Abstract
The anorectic drugs cloforex, at 3, 25, and 75 mg per kilogram of body weight, and chlorphentermine, at 75 mg/kg, were administered daily by gavage to adult male white rats for up to 6 wk to study their induction and reversal of pulmonary lipid histiocytosis. Systemic lipidosis, pulmonary hypertension, hematologic effects, and anorectic properties were also evaluated. Rats given 75 mg/kg cloforex or chlorphentermine showed hair loss and agitation; both weight gain and food consumption were suppressed, but these suppressive effects disappeared rapidly when the drugs were stopped. Cloforex at 25 mg/kg inhibited food consumption but not weight gain. These results confirm that the rat is highly resistant to the anorectic effects of these drugs. Pulmonary hypertension was assessed by measuring the weight ratio of the left and right ventricles of the heart and by measuring the thickness of pulmonary artery mediae as a percentage of the vessel diameters. There was no evidence of pulmonary hypertension, even in a...