H. Takikawa, T. Takemura, M. Yamanaka
1995
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Influential Citations
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Quality indicators
Journal
International Hepatology Communications
Abstract
Abstract Tauroursodeoxycholate has been reported to prevent cholestasis in experimental models. However, its uptake mechanism by the liver has only been speculated from the results of taurocholate. In the present study, the mechanism of tauroursodeoxycholate uptake was studied in isolated rat hepatocytes. Tauroursodeoxycholate uptake was mainly Na+-dependent in lower substrate concentrations, whereas about a half of the hepatic uptake became Na+-independent at concentrations of more than 100 μM. Tauroursodeoxycholate uptake was competitively inhibited by taurocholate. These findings indicate that in the hepatic uptake of tauroursodeoxycholate in a physiological condition, Na+-dependent transport is predominant, and that Na+-independent transport is also activated at its higher concentration.