S. Mirvish, M. Greenblatt, V. Kommineni
May 1, 1972
Citations
2
Influential Citations
27
Citations
Quality indicators
Journal
Journal of the National Cancer Institute
Abstract
Swiss mice were treated For 6 months with methylurea (5.36 g/kg Food) or ethylurea (6.36 g/kg Food) together with sodium nitrite (1.0 g/Iiter drinking water). In both groups, more than 4 lung adenomas/mouse were induced. The alkyl urea-plus-nitrite groups also had a small increase in malignant lymphomas. Similar treatment with methylurea or ethylurea alone had no effect. The results indicate that the lung adenomas were induced by methylnitrosourea and ethylnitrosourea, Formed by in vivo nitrosation of the corresponding alkylureas. The possible public health implications of ureide nitrosation in vivo are discussed.-J Nat Cancer Inst 48: 1311-1315, 1972.